MFAP3 Antibody (1059216) [Alexa Fluor® 700]

• Reactivity: Hu
• Applications: IHC
• Clone: 1059216
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 700

MFAP3 Antibody (1059216) [Alexa Fluor® 700] Summary

• Immunogen: Human embryonic kidney cell, HEK293-derived human MFAP3
  Leu22-Met147
  Accession # P55082
• Specificity: Detects human MFAP3 in direct ELISA.
• Isotype: IgG1
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for MFAP3 Antibody (1059216) [Alexa Fluor® 700]

• DKFZp586F0219
• MFAP3
• microfibril-associated glycoprotein 3
• microfibrillar-associated protein 3

Background

Microfibril-associated glycoprotein 3 (MFAP3), is a member of the MFAP family which play a role in microfibril assembly, elastinogenesis, and tissue homeostasis. The family members were identified as potential components of fibrillin-containing microfibrils, but they do not share structural similarities (1). MFAP3 is found in ocular zonules. Human MFAP3 is a serine-rich acidic protein located in zonular fibers and consists of an extracellular domain (ECD) containing one Ig-like C2-type domain, a single transmembrane domain, and a cytoplasmic domain. Within the ECD, mature human MFAP3 shares 74% amino acid sequence identity with mouse and rat MFAP3. Among MFAP3-related pathways are degradation of the extracellular matrix and elastic fiber formation. MFAP is a candidate gene for heritable diseases affecting microfibrils (2).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.