Methylated Lysine Antibody [Biotin] Summary
Methylated Lysine conjugated to KLH.
Detects proteins containing methylated lysine residues in SDS-PAGE immunoblots. Detects proteins containing methylated lysine residues. There is no cross-reaction with acetylated lysine. Cross-reactivity with tri-methyllysine has not yet been tested.
Immunogen affinity purified
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Packaging, Storage & Formulations
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Biotin (A=N/A, E=N/A)
Immunogen affinity purified
Alternate Names for Methylated Lysine Antibody [Biotin]
- Methyl lysine
- N epsilon dimethyl lysine
- N epsilon mono methyllysine
- N epsilon trimethyl lysine
- N(epsilon) trimethyl lysine
- Trimethyl lysine
Post-translational modifications of proteins play critical roles in the regulation and function of many known
biological processes. Proteins can be post-translationally modified in many different ways, and a common posttranscriptional modification of Lysine involves methylation (1). Lysine can be methylated once, twice or three times by lysine methyltransferases. The transfer of methyl groups from S-adenosyl methionine to histones is
catalyzed by enzymes known as histone
methyltransferases. Histones which are methylated on certain residues can act epigenetically to repress or activate gene expression (1, 2). The transcriptional repressor SUV39H1 can encode novel enzymes which selectively methylate histone H3 at lysine 9. SUV39H1 places a methyl marker on histone H3, which is then recognized by HP1 through its chromo domain. This model may also explain the stable inheritance of the heterochromatic state (3). Some studies have also speculated a stimulatory role for transcription by
methylated histone lyside 4 due to its presence at active transcription sites (4-6).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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