Western Blot: metabotropic Glutamate Receptor 1a Antibody [NB300-123] - 10 ug of HEK 293 cells expression. As shown in the autoradiograph, the mGluR1a antibody is specific for the ~125k monomer and the ~250k dimer of ...read more
Western Blot: metabotropic Glutamate Receptor 1a Antibody [NB300-123] - 10 ug of HEK 293 cells expressing mGluR1a and mGluR5 showing the specific immunolabeling of the ~125k monomer and the ~250k dimer of mGluR1a. The ...read more
WB, IHC, IHC-Fr
Please see the vial label for concentration. If unlisted please contact technical services.
Alternate Names for metabotropic Glutamate Receptor 1a Antibody
glutamate receptor, metabotropic 1
metabotropic glutamate receptor 1
The Metabotropic Glutamate Receptor mGluR1 binds L-glutamate, the major excitatory neurotransmitter in the central nervous system, which activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. mGluR1 and mGluR5 are group I receptors that have been shown to activate phospholipase C. Alternative splice variants of the mGluR1 gene have been described, but their full-length nature has not been determined. Inflammation results in the activation of mGluR1 and mGluR5 in dorsal horn neurons of the spinal cord, leading to extracellular signal-regulated kinase (ERK) activation, which is required for nociceptive plasticity and enhanced pain. mGluR1 has been reported in various regions of the brain and spinal cord. ESTs have been isolated from brain and eye libraries. Caution: GLUR1 refers to Ionotropic Glutamate Receptor 1, not to Metabotropic Glutamate Receptor 1 (mGLUR1).
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.