MEK2 Antibody (8G6)

Images

 
Western Blot: MEK2 Antibody (8G6) [NBP1-47836] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MEK2 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ...read more
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Human pancreas tissue using anti-MEK2 mouse monoclonal antibody.
Flow Cytometry: MEK2 Antibody (8G6) [NBP1-47836] - HEK293T cells transfected with either overexpression plasmid (Red) or empty vector control plasmid (Blue) were immunostained by anti-MEK2 antibody, and then analyzed by ...read more
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Adenocarcinoma of Human breast tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Adenocarcinoma of Human colon tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Carcinoma of Human thyroid tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Human breast tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Human endometrium tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Human Kidney tissue using anti-MEK2 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: MEK2 Antibody (8G6) [NBP1-47836] - Staining of paraffin-embedded Human lung tissue using anti-MEK2 mouse monoclonal antibody.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, IHC-P
Clone
8G6
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

MEK2 Antibody (8G6) Summary

Immunogen
Protein expressed in 293T cell transfected with human MAP2K2 expression vector
Specificity
This antibody is specific for Homo sapiens mitogen-activated protein kinase kinase 2 (MAP2K2).
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
MAP2K2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Flow Cytometry 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for MEK2 Antibody (8G6)

  • ERK activator kinase 2
  • MAP2K2
  • MAPKK 2
  • MEK 2
  • MEK2
  • MEK2EC 2.7.12.2
  • mitogen-activated protein kinase kinase 2
  • MKK2
  • MKK2FLJ26075
  • p45
  • PRKMK2MAPKK2

Background

The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is known to play a critical role in mitogen growth factor signal transduction. It phosphorylates and thus activates MAPK1/ERK2 and MAPK2/ERK3. The activation of this kinase itself is dependent on the Ser/Thr phosphorylation by MAP kinase kinase kinases.Mutations in this gene cause cardiofaciocutaneous syndrome (CFC syndrome), a disease characterized by heart defects, mental retardation, and distinctive facial features similar to those found in Noonan syndrome. The inhibition or degradation of this kinase is also found to be involved in the pathogenesis of Yersinia and anthrax. A pseudogene, which is located on chromosome 7, has been identified for this gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MAP2K2
Entrez