55 kDa. Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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MEF-2 is a muscle-specific DNA binding protein that recognizes an A+T-rich sequence [CTA (A/T)4 TAG] localized in the control regions of numerous muscle-specific genes. MEF-2 belongs to the MADS (MCM1, Agamous, Deficiens and serum-response factor) box family of transcription factors. The MEF-2 proteins arise from several alternatively spliced isoforms of the MEF-2 gene. MEF-2 expression is ubiquitous, but appears to be preferential in skeletal and cardiac muscle cells. Phosphorylation of different MEF-2C isoforms affects their expression pattern and transactivation function. Big MAP kinase 1 (BMK1) enhances the transactivation activity of MEF-2C by phosphorylating Ser 387. Serum is a potent stimulator of BMK1-induced MEF-2C phosphorylation. p38 MAPK can phosphorylate MEF-2C at positions Ser 387, Thr 293 and Thr 300. Phosphorylation of MEF-2C by either p38 MAPK or ERK5/BMK1 is necessary for Smad-MEF-2 signaling cooperativity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
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