Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
PBS, pH 7.2.
0.05% Sodium Azide
Immunogen affinity purified
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Read Publication using NB100-92578 in the following applications:
MEF-2 is a muscle-specific DNA binding protein that recognizes an A+T-rich sequence [CTA (A/T)4 TAG] localized in the control regions of numerous muscle-specific genes. MEF-2 belongs to the MADS (MCM1, Agamous, Deficiens and serum-response factor) box family of transcription factors. The MEF-2 proteins arise from several alternatively spliced isoforms of the MEF-2 gene. MEF-2 expression is ubiquitous, but appears to be preferential in skeletal and cardiac muscle cells. Phosphorylation of different MEF-2C isoforms affects their expression pattern and transactivation function. Big MAP kinase 1 (BMK1) enhances the transactivation activity of MEF-2C by phosphorylating Ser 387. Serum is a potent stimulator of BMK1-induced MEF-2C phosphorylation. p38 MAPK can phosphorylate MEF-2C at positions Ser 387, Thr 293 and Thr 300. Phosphorylation of MEF-2C by either p38 MAPK or ERK5/BMK1 is necessary for Smad-MEF-2 signaling cooperativity.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.