MDR1/ABCB1 Antibody

Product Discontinued

MDR1/ABCB1 Antibody Summary

• Immunogen: Synthetic peptide, corresponding to amino acids 551-600 of Human Mdr-1.
• Clonality: Polyclonal
• Host: Rabbit
• Gene: ABCB1
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
• Application Notes: Immunohistochemistry (IHC) analyzes of Mdr-1 (I583) pAb in paraffin-embedded human brain tissue.

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for MDR1/ABCB1 Antibody

• ABC20
• ABCB1
• ABCB1B
• ATP-binding cassette sub-family B member 1
• ATP-binding cassette, sub-family B (MDR/TAP), member 1
• CD243 antigen
• CD243
• CLCS
• colchicin sensitivity
• doxorubicin resistance
• EC 3.6.3
• EC 3.6.3.44
• GP170
• IBD13
• MDR1
• MDR1MGC163296
• multidrug resistance protein 1
• P-glycoprotein 1
• P-gp
• PGY1
• PGY1P-GP

Background

Cells selected for resistance to a single cytotoxic drug may become crossresistant to a broad range of drugs with different structures and cellular targets. This phenomenon is called multiple drug resistance (MDR). The MDR proteins (Mdrs) are members of a highly conserved superfamily of ATPbinding cassette transport proteins. Mdr functions as an energy-dependent efflux pump for structurally diverse agents ranging from ions to peptides. It is implicated in the development of the multiple drug resistance observed in human cancer cells following prolonged chemotherapy. The classic form of MDR is associated with an increase in the Mdr protein, but not all cases of MDR can be attributed to a rise in Mdr levels. Mdr-1 is an apical transmembrane protein that is an integral part of the blood-brain barrier and functions as a drug-transport pump transporting a variety of drugs from the brain back into the blood. In the human population, there are 15 polymorphisms in the Mdr-1 gene.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Review for MDR1/ABCB1 Antibody (NBP1-19787) (1)

Average Rating: 4

(Based on 1 review)

We have 1 review tested in 1 species: Other.

reviewed by: Verified Customer IHC-P Other 12/28/2011

Summary

• Application: Immunohistochemistry-Paraffin
• Sample Tested: Human Brain Tissue
• Species: Other

FAQs for MDR1/ABCB1 Antibody (NBP1-19787). (Showing 1 - 1 of 1 FAQ).

1. Can NBP1-19787 be used in IHC-Fr?
   • NBP1-19787 has been validated and is guaranteed to work in IHC-Paraffin. IHC-Frozen is not one of the guaranteed applications. If you would be interested in testing this novel application, please take a look at our Innovators Reward Program.

Bioinformatics

• Gene Symbol: ABCB1
• Entrez:
  • 5243(Human)
  • 18669(Mouse)
  • 24646(Rat)
• Uniprot:
  • P08183(Human)