MBL Antibody (3E7)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-42419
    • Availability
      Product Discontinued

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MBL Antibody (3E7) Summary

Immunogen
The antibody reacts with the MBL antigen.
Specificity
Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of Collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q–independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
MBL2
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
Application Notes
The monoclonal antibody 3E7 can be used for blocking the complement-activating capacity of human MBL. The antibody 3E7 is useful for Western blotting and immuno assays. Furthermore the monoclonal antibody 3E7 is useful for immunohistology on frozen sectioFor Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For neutralization of biological activity dilutions have to be made according to the amounts MBL to be inactivated. Before use in biological assays depending on the assay to be performed it may be necessary to filter sterilise the product. Depending on the concentration to be used the product should be dialyzed against culture medium to remove the sodium azide added.

Reactivity Notes

Rat

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS containing 0.1% BSA
Preservative
0.02% Sodium Azide
Purity
Protein A or G purified

Alternate Names for MBL Antibody (3E7)

  • COLEC1
  • COLEC1collectin-1
  • Collectin-1
  • HSMBPC
  • Mannan-binding protein
  • mannose-binding lectin (protein C) 2, soluble (opsonic defect)
  • mannose-binding lectin (protein C) 2, soluble
  • Mannose-binding lectin
  • mannose-binding protein C
  • MBL
  • MBL2
  • MBL2D
  • MBLmannan-binding lectin
  • MBP
  • MBP1
  • MBP1mannose-binding lectin 2, soluble (opsonic defect)
  • MBP-C
  • MGC116832
  • MGC116833

Background

Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MBL2
Entrez