MBL Antibody (3E7)



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MBL Antibody (3E7) Summary

The antibody reacts with the MBL antigen.
Mannose Binding Lectin (MBL) also called mannose- or mannan-binding protein (MBP) is a member of the group of Collectins. MBL is an oligomeric lectin that recognizes carbohydrates as mannose and N-acetylglucosamine on pathogens. MBL contains a cysteine rich, a collagen like and a carbohydrate recognition domain. It forms a complex with C1r/C1s like serine proteases designated MASPs that proteolytically cleave C4, C2 and C3. MBL is able to activate the complement pathway independent of the classical and alternative complement activation pathways. The MBL-MASP pathway (better known as the lectin pathway) is antibody and C1q–independent. MBL exhibits complement-dependent antibacterial activity and acts directly as an opsonic and therefore plays an important role in innate immunity. MBL is synthesized by hepatocytes and has been isolated from the liver or serum of various vertebrate species.
Protein A or G purified
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Packaging, Storage & Formulations

Store at 4C. Do not freeze.
PBS containing 0.1% BSA
0.02% Sodium Azide
Protein A or G purified


Application Notes
The monoclonal antibody 3E7 can be used for blocking the complement-activating capacity of human MBL. The antibody 3E7 is useful for Western blotting and immuno assays. Furthermore the monoclonal antibody 3E7 is useful for immunohistology on frozen sectioFor Western blotting, flow cytometry and immunohistology dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:50. For neutralization of biological activity dilutions have to be made according to the amounts MBL to be inactivated. Before use in biological assays depending on the assay to be performed it may be necessary to filter sterilise the product. Depending on the concentration to be used the product should be dialyzed against culture medium to remove the sodium azide added.

Reactivity Notes



Cytomegalovirus is a member of the herpes virus group, which includes herpes simplex virus types 1 and 2, varicella zoster virus (which causes chicken pox), and Epstein Barr virus (which causes infectious mononucleosis). These viruses share a characteristic ability to remain dormant within the body over a long period.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol MBL2

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