MBD1 Antibody



Product Details

Product Discontinued
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MBD1 Antibody Summary

Synthetic peptide: C-RSKDLKKPGARKQ, corresponding to amino acids 593-605 of Human MBD 1.
This detects human methyl CpG binding domain protein 1 (MBD1) recombinant protein.
Immunogen affinity purified
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Packaging, Storage & Formulations

Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
PBS with 1 mg/ml BSA
0.05% Sodium Azide
Concentrations vary lot to lot. See vial label for concentration. If unlisted please contact technical services.
Immunogen affinity purified


Application Notes
This antibody can be used in Western Blot where a 83 kDa band is seen. Recommended Starting Dilutions*: WB: 2-5 ug/ml *Optimal dilutions should be determined by the end user.

Reactivity Notes

Cross-reacts with Human. Not yet tested in other species.


Methyl CpG binding domain proteins (MBDs) are a family of mammalian proteins that specifically bind methylated regions of DNA. There are two methyl CpG binding complexes, MeCP1 and MeCP2. MeCP2 is comprised of a single protein also denoted MeCP2. MeCP1 is composed of four different proteins termed MBD1 (also known as PCM1), MBD2, MBD3, and MBD4 (also known as MED1). MBD1 binds to and represses transcription of symmetrically methylated CpG sequences. MBD1 is the only protein in the MeCP1 complex than contains a CXXC motif (Dnmt DNA binding motif). MBD1 also contains both a methyl CpG binding domain and a transcriptional repression domain at the C-terminus. It has been suggested that the mechanism for methylation-dependent repression is likely to involve other chromatin modifications including histone deacetylation since inhibitors of deacetylase activity have been shown to overcome MBD1-mediated gene repression.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Contact Information

Product PDFs


Gene Symbol MBD1

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