MBD1 Antibody

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Western Blot: MBD1 Antibody [NB300-559] - Recombinant human MBD1 protein.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB300-559
    • Availability
      Product Discontinued

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MBD1 Antibody Summary

Immunogen
Synthetic Peptide: C R(593) S K D L K K P G A R K Q(605)
Localization
Nuclear
Specificity
This detects human methyl CpG binding domain protein 1 (MBD1) recombinant protein.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MBD1
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 2 - 5 ug/ml
Application Notes
WB: Detects a 83 kDa protine is seen.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 1 mg/ml BSA
Preservative
0.05% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MBD1 Antibody

  • CXXC-type zinc finger protein 3
  • methyl-CpG binding domain protein 1 isoform PCM1
  • methyl-CpG binding domain protein 1
  • methyl-CpG-binding domain protein 1
  • Methyl-CpG-binding protein MBD1
  • PCM1CXXC3RFT
  • Protein containing methyl-CpG-binding domain 1
  • the regulator of fibroblast growth factor 2 (FGF-2) transcription

Background

Methyl CpG binding domain proteins (MBDs) are a family of mammalian proteins that specifically bind methylated regions of DNA. There are two methyl CpG binding complexes, MeCP1 and MeCP2. MeCP2 is comprised of a single protein also denoted MeCP2. MeCP1 is composed of four different proteins termed MBD1 (also known as PCM1), MBD2, MBD3, and MBD4 (also known as MED1). MBD1 binds to and represses transcription of symmetrically methylated CpG sequences. MBD1 is the only protein in the MeCP1 complex than contains a CXXC motif (Dnmt DNA binding motif). MBD1 also contains both a methyl CpG binding domain and a transcriptional repression domain at the C-terminus. It has been suggested that the mechanism for methylation-dependent repression is likely to involve other chromatin modifications including histone deacetylation since inhibitors of deacetylase activity have been shown to overcome MBD1-mediated gene repression.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional MBD1 Products

Bioinformatics Tool for MBD1 Antibody (NB300-559)

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Bioinformatics

Gene Symbol MBD1