MAVS Overexpression Lysate (Denatured) Summary
Plasmid: pCMV-VISA full-length
Packaging, Storage & Formulations
Store at -80C. Avoid freeze-thaw cycles.
Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).
Lysate Details for MAVS
Quality control test: Transient overexpression cell lysate was tested with Anti-VISA antibody by Western Blots.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for MAVS Overexpression Lysate (Denatured)
- CARD adapter inducing interferon beta
- CARD adapter inducing interferon-beta
- CARD adaptor inducing IFN-beta
- IFN-B promoter stimulator 1
- Interferon beta promoter stimulator protein 1
- interferon-beta promoter stimulator protein 1
- mitochondrial antiviral signaling protein
- mitochondrial antiviral-signaling protein
- mitochondrial viral signaling protein
- Putative NF-kappa-B-activating protein 031N
- virus-induced signaling adapter variant 1b
- virus-induced signaling adaptor variant 1a
- Virus-induced-signaling adapter
Double-stranded RNA viruses are recognized in a cell type-dependent manner by the transmembrane receptor TLR3 (MIM 603029) or by the cytoplasmic RNA helicases MDA5 (MIM 606951) and RIGI (ROBO3; MIM 608630). These interactions initiate signaling pathways that differ in their initial steps but converge in the activation of the protein kinases IKKA (CHUK; MIM 600664) and IKKB (IKBKB; MIM 603258), which activate NFKB (see MIM 164011), or TBK1 (MIM 604834) and IKKE (IKBKE; MIM 605048), which activate IRF3 (MIM 603734). Activated IRF3 and NFKB induce transcription of IFNB (IFNB1; MIM 147640). For the TLR3 pathway, the intermediary molecule before the pathways converge is the cytoplasmic protein TRIF (TICAM1; MIM 607601). For RIGI, the intermediary protein is mitochondria-bound IPS1 (Sen and Sarkar, 2005 [PubMed 16239922]).[supplied by OMIM]
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed
for 6 months from date of receipt.
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Product General Protocols
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FAQs for MAVS Lysate (H00057506-T01). (Showing 1 - 1 of 1 FAQ).
Molecular weight of MAVS?
- MAVS is a 540 aa protein with a predicted size of 56 kDa.
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