MAPKAPK2 Antibody

Images

 
Western Blot: MAPKAPK2 Antibody [NBP1-51331] - Extracts from COS cells.
Immunohistochemistry-Paraffin: MAPKAPK2 Antibody [NBP1-51331] - Paraffin-embedded human breast carcinoma tissue at 1:100.

Product Details

Summary
Product Discontinued
View other related MAPKAPK2 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51331
    • Availability
      Product Discontinued

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MAPKAPK2 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 250-300 of Human MAPKAPK-2.
Specificity
MAPKAPK-2 (N266) pAb detects endogenous levels of MAPKAPK-2 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
MAPKAPK2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of MAPKAPK-2 (N266) pAb in extracts from COS cells.
Immunohistochemistry (IHC) analyzes of MAPKAPK-2 (N266) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
46 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MAPKAPK2 Antibody

  • EC 2.7.11
  • EC 2.7.11.1
  • MAP kinase-activated protein kinase 2
  • MAPK-activated protein kinase 2
  • MAPKAP kinase 2
  • MAPKAPK2
  • MAPKAPK-2
  • mitogen-activated protein kinase-activated protein kinase 2
  • MK2
  • Rps6kc1

Background

MAP kinase activated protein kinase 2 (MAPKAP Kinase 2), also known as p45 hsp27 kinase, is a 45-54 kDa serine/threonine protein kinase that contains a proline rich sequence and two putative SH3 binding sites. MAPKAP Kinase 2 is activated in response to stress, IL1 and TNF, possibly catalyzed by p38/Hog dependent phosphorylation. One of the major substrates of MAPKAP Kinase 2 is hsp27, which stimulates actin polymerization in order to facilitate recovery from destruction of cytoskeleton during cellular stresses. MAPKAP2 is implicated in several disorders including ischemic brain injury and heart failure and has been shown to be important in regulating stress resistance and the production of TNF alpha.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol MAPKAPK2
Entrez