MAML2 Antibody

Images

 
Independent Antibodies: Western Blot: MAML2 Antibody [NB100-2127] - Detection of Human and Mouse MAML2 on HeLa whole cell lysate using NB100-2127. MAML2 was also immunoprecipitated by another rabbit anti-MAML2 ...read more
Immunohistochemistry-Paraffin: MAML2 Antibody [NB100-2127] - Human breast carcinoma. Antibody: Affinity purified rabbit anti-MAML2 used at a dilution of 1:200 (1ug/ml). Detection: DAB

Product Details

Summary
Reactivity Hu, Mu, BvSpecies Glossary
Applications WB, IHC, IHC-P, IP
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Concentration
0.2 mg/ml

Order Details

MAML2 Antibody Summary

Immunogen
The immunogen recognized by this antibody maps to a region between residue 1100 and the C-terminus (residue 1153) of human Mastermind-Like 2 using the numbering given in entry AAK93831.1 (GeneID 84441).
Predicted Species
Bovine (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
MAML2
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Immunohistochemistry 1:200 - 1:1000
  • Immunohistochemistry-Paraffin 1:200 - 1:1000
  • Immunoprecipitation 1-4 ug/mg of lysate
  • Western Blot 1:2000-1:15000
Application Notes
Epitope retrieval with Tris-EDTA pH 9.0 is recommended for FFPE tissue sections.
Publications
Read Publication using NB100-2127.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
TBS and 0.1% BSA
Preservative
0.09% Sodium Azide
Concentration
0.2 mg/ml
Purity
Immunogen affinity purified

Alternate Names for MAML2 Antibody

  • DKFZp686N0150
  • KIAA1819MGC176701
  • MAM2
  • mam-2
  • MAM-3
  • MAM3MLL-MAML2
  • mastermind (Drosophila)-like 2
  • mastermind-like 2 (Drosophila)
  • mastermind-like protein 2

Background

There are 3 MAML (mastermind-like) proteins in mammals (MAML1-3). MAML2 is a critical coactivator for NOTCH signaling. MAML2 associates with NOTCH and CSL in a ternary complex and functions to activate transcription of HES and hairy-related basic helix-loop-helix transcription factors. MAML2 has been identified in a chromosomal rearrangement and fusion with MECT1 in mucoepidermoid carcinomas, secondary acute myeloid leukemia, hidradenomas, and myelodysplastic syndrome. MECT1 is a CREB regulator, and when fused with the transactivational domain of MAML2, imparts constitutive activation of CREB-dependent transcription that may promote oncogenesis. Alternate names for MAML2 include Mam-2, MAM2, MAM3, MAM-3, MLL-MAML2, MGC176701, DKFZp686N0150, and KIAA1819.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for MAML2 Antibody (NB100-2127)(1)

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol MAML2
Entrez
Uniprot