MAML2 Antibody (MAML2/1302)

Images

 
Immunohistochemistry-Paraffin: MAML2 Antibody (MAML2/1302) [NBP2-47649] - Formalin-fixed, paraffin-embedded Human Placenta stained with MAML2 Monoclonal Antibody (MAML2/1302).
Immunohistochemistry-Paraffin: MAML2 Antibody (MAML2/1302) [NBP2-47649] - Formalin-fixed, paraffin-embedded Human Pancreas stained with MAML2 Monoclonal Antibody (MAML2/1302).
Immunohistochemistry-Paraffin: MAML2 Antibody (MAML2/1302) [NBP2-47649] - Formalin-fixed, paraffin-embedded Human Colon Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).
Immunohistochemistry-Paraffin: MAML2 Antibody (MAML2/1302) [NBP2-47649] - Formalin-fixed, paraffin-embedded Human Bladder Carcinoma stained with MAML2 Monoclonal Antibody (MAML2/1302).
SDS-Page: MAML2 Antibody (MAML2/1302) [NBP2-47649]

Product Details

Summary
Product Discontinued
View other related MAML2 Primary Antibodies

Order Details


    • Catalog Number
      NBP2-47649
    • Availability
      Product Discontinued

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MAML2 Antibody (MAML2/1302) Summary

Immunogen
Recombinant human MAML2 fragment
Localization
Cytoplasmic
Specificity
MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-Jk; a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.
Isotype
IgG
Clonality
Monoclonal
Host
Mouse
Gene
MAML2
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.5-1ug/ml
  • Flow Cytometry 0.5-1ug/million cells
  • Immunohistochemistry-Paraffin 0.5-1.0ug/ml
  • SDS-Page
  • Immunofluorescence 0.5-1ug/ml
Application Notes
Hu Chromosome Location: 11q21
Immunohistology (Formalin-fixed) (0.5-1.0ug/ml for 30 minutes at RT) (Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10mM Tris with 1mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)
Theoretical MW
125 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for MAML2 Antibody (MAML2/1302)

  • DKFZp686N0150
  • KIAA1819MGC176701
  • MAM2
  • mam-2
  • MAM-3
  • MAM3MLL-MAML2
  • mastermind (Drosophila)-like 2
  • mastermind-like 2 (Drosophila)
  • mastermind-like protein 2

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol MAML2