M-CSF R/CD115 Antibody (12-3A3-1B10) [Biotin]

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Flow Cytometry: M-CSF R/CD115 Antibody (12-3A3-1B10) [Biotin] [NBP1-43591] - Staining of normal human peripheral blood cells with 0.06 ug of Rat IgG2b K Isotype Control Biotin (open histogram) or 0.06 ug of Anti-Human ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow
Clone
12-3A3-1B10
Clonality
Monoclonal
Host
Rat
Conjugate
Biotin
Concentration
0.5 mg/ml

M-CSF R/CD115 Antibody (12-3A3-1B10) [Biotin] Summary

Immunogen
The immunogen for this antibody was CD115.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
CSF1R
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for M-CSF R/CD115 Antibody (12-3A3-1B10) [Biotin]

  • CD115 antigen
  • CD115
  • c-fms
  • colony stimulating factor 1 receptor
  • CSF1R
  • CSF-1-R
  • CSFR
  • EC 2.7.10.1
  • FMS proto-oncogene
  • FMSFIM2
  • macrophage colony stimulating factor I receptor
  • macrophage colony-stimulating factor 1 receptor
  • McDonough feline sarcoma viral (v-fms) oncogene homolog
  • M-CSF R
  • MCSFR
  • M-CSFR
  • Proto-oncogene c-Fms

Background

CD115 or Colony-Stimulating Factor-1 Receptor (CSF-1R) is expressed on cells committed to the monocyte lineage and osteoclasts. CSF-1R is a disulfide-linked homodimer, which upon binding of its ligand, CSF-1, undergoes tyrosine autophosphorylation and subsequently, phosphorylates other membrane-proximal downstream targets which results in cytoskeletal remodeling, gene transcription and protein translation. CSF-1R activation promotes the survival, proliferation and differentiation of mononuclear phagocytes and the spreading and motility of macrophages. In osteoclasts, CSF-1R synergizes with RANKL to regulate the differentiation of mononuclear phagocytes to osteoclasts.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Diseases for M-CSF R/CD115 Antibody (NBP1-43591)

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Bioinformatics

Gene Symbol CSF1R
Entrez