Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB

Order Details

Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured) Summary

Description
Pasmid: pCMV-PRCP full-length
Gene
PRCP

Packaging, Storage & Formulations

Storage
Store at -80C. Avoid freeze-thaw cycles.
Buffer
Sample Buffer (50 mM Tris-HCl, 2% SDS, 10% glycerol, 300 mM 2-mercaptoethanol, and 0.01% Bromophenol blue).

Lysate Details for Lysosomal Pro-X Carboxypeptidase/PRCP

Type
Overexpression
Protein State
Denatured

Notes

Quality control test: Transient overexpression cell lysate was tested with Anti-PRCP antibody by Western Blots.

This product is produced by and distributed for Abnova, a company based in Taiwan.

Alternate Names for Lysosomal Pro-X Carboxypeptidase/PRCP Overexpression Lysate (Denatured)

  • Angiotensinase C
  • EC 3.4.16.2
  • HUMPCP
  • Lysosomal carboxypeptidase C
  • lysosomal Pro-X carboxypeptidase
  • PCPMGC2202
  • PRCP
  • Proline carboxypeptidase
  • prolylcarboxypeptidase (angiotensinase C)
  • prolylcarboxypeptidase isoform 1 preproprotein
  • Prolylcarboxypeptidase

Background

The protein encoded by this gene is a lysosomal prolylcarboxypeptidase, which cleaves C-terminal amino acids linked to proline in peptides such as angiotension II, III and des-Arg9-bradykinin. The cleavage occurs at acidic pH, but the enzyme activity is retained with some substrates at neutral pH. This enzyme has been shown to be an activator of the cell matrix-associated prekallikrein. The importance of angiotension II, one of the substrates of this enzyme, in regulating blood pressure and electrolyte balance suggests that this gene may be related to essential hypertension. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq]. Transcript Variant: This variant (2) represents the longer transcript and encodes the longer isoform (2). Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Lysates are guaranteed for 6 months from date of receipt.

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Publications for Lysosomal Pro-X Carboxypeptidase/PRCP Lysate (H00005547-T01) (0)

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Bioinformatics

Gene Symbol PRCP
Entrez