Lyn Antibody

Images

 
Western Blot: Lyn Antibody [NBP1-57583] - Human Fetal Heart, Antibody Dilution: 1.0 ug/ml.
Western Blot: Lyn Antibody [NBP1-57583] - Hela cell lysate, concentration 0.2-1 ug/ml.
Western Blot: Lyn Antibody [NBP1-57583] - Human Fetal Brain, Antibody Dilution: 1.0 ug/ml.
Western Blot: Lyn Antibody [NBP1-57583] - Human Fetal Lung, Antibody Dilution: 1.0 ug/ml.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-57583
    • Availability
      Product Discontinued

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Lyn Antibody Summary

Immunogen
Synthetic peptides corresponding to LYN (v-yes-1 Yamaguchi sarcoma viral related oncogene homolog) The peptide sequence was selected from the N terminal of LYN)(50ug). Peptide sequence DPTSNKQQRPVPESQLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSF.
Clonality
Polyclonal
Host
Rabbit
Gene
LYN
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Application Notes
This is a rabbit polyclonal antibody against LYN and was validated on Western blot.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS and 2% Sucrose
Preservative
0.09% Sodium Azide
Purity
Immunogen affinity purified

Notes

The addition of 50% glycerol is optional for those storing this antibody at -20C and not aliquoting smaller units. However, please note that glycerol may interrupt some downstream antibody applications and should be added with caution.

Alternate Names for Lyn Antibody

  • EC 2.7.10
  • EC 2.7.10.2
  • FLJ26625
  • Hck-2
  • JTK8
  • Lyn
  • tyrosine-protein kinase Lyn
  • v-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  • v-yes-1
  • Yamaguchi sarcoma viral (v-yes-1) related oncogene homolog

Background

LYN down regulates expression of stem cell growth factor receptor (KIT).LYN acts as an effector of EpoR (erythropoietin receptor) in controlling KIT expression and may play a central role in erythroid differentiation during the switch between proliferation and maturation.LYN acts as a positive regulator of cell movement while negatively regulating adhesion to stromal cells by inhibiting the ICAM-1-binding activity of beta-2 integrins. LYN acts as the mediator that relays suppressing signals from the chemokine receptor CXCR4 to beta-2 integrin LFA-1 in hematopoietic precursors. Involved in induction of stress-activated protein kinase (SAPK), but not ERK or p38 MAPK, in response to genotoxic agents.LYN induces SAPK by a MKK7- and MEKK1-dependent mechanism. The LYN -> MEKK1 -> MKK7 -> SAPK pathway is functional in the induction of apoptosis by genotoxic agents.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

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Secondary Antibodies

 

Isotype Controls

Additional Lyn Products

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Bioinformatics

Gene Symbol LYN
Entrez
Uniprot