Lymphotoxin beta R/TNFRSF3 Antibody

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB110-8557
    • Availability
      Product Discontinued

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Lymphotoxin beta R/TNFRSF3 Antibody Summary

Immunogen
Recombinant human lymphotoxin betaR extracellular domain, expressed in mouse NSO cells.
Localization
Membrane; single pass type I membrane protein.
Specificity
LTBR
Clonality
Polyclonal
Host
Goat
Gene
LTBR
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 0.1-0.2 ug/ml
  • ELISA 0.5-1.0 ug/ml
Application Notes
For ELISA: 0.5-1.0 ug/ml to detect a limit of 0.16 ng/well of recombinant human lymphotoxin beta receptor

Reactivity Notes

Human.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS and 5% Trehalose
Preservative
No Preservative
Concentration
0.1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody

  • CD18
  • D12S370
  • ltbetar
  • LT-BETA-R
  • LTBR
  • lymphotoxin B receptor
  • Lymphotoxin beta R
  • lymphotoxin beta receptor (TNFR superfamily, member 3)
  • Lymphotoxin-beta receptor
  • LymphotoxinbR
  • TNF RIII
  • TNF Rrp
  • TNFCRTNF-RIII
  • TNFR superfamily, member 3
  • TNFR2-RP
  • TNFR3
  • TNF-R-III
  • TNFR-RP
  • TNFRSF3
  • TNFRSF3TNFR-III
  • Tumor necrosis factor C receptor
  • Tumor necrosis factor receptor 2-related protein
  • tumor necrosis factor receptor superfamily member 3
  • tumor necrosis factor receptor superfamily, member 3
  • Tumor necrosis factor receptor type III

Background

Tumor necrosis factor-beta (TNF-beta), also known as lymphotoxin (LT or LT-a) and cytotoxic factor, is a 25 kDa glycoprotein that is tightly regulated by lymphocytes. TNF-beta and TNF-alpha share a 28% amino acid sequence identity, and as soluble forms, both can exist in solution as homotrimers, activate the same TNF receptors (TNFR1 and TNFR2) and elicit many of the same bioactivities. Unlike TNF-alpha, TNF-beta can also form heterotrimers with one or two molecules of the related membrane-bound lymphotoxin-beta (LT-beta). Reportedly, LT-alpha1/beta2, the predominant heterotrimer, binds and activates only the LT-beta receptor, LT-betaR. The other heterotrimer, LT-alpha2/beta1 binds and activates TNFR1 and TNFR2 but not LT-betaR. TNF-beta is expressed in activated T, B and NK cells and in certain transformed cells. Genes for TNF-beta, LT-beta and TNF-alpha are tightly linked near each other within the MHC. TNF-beta appears to play many of the same biological roles as TNF-alpha, but the membrane-bound form with LT-beta is critical for normal lymphoid organ development. Genetic polymorphisms in TNF-alpha and TNF-beta have been linked to certain pathological conditions, including myasthenia gravis. At the amino acid level, human and mouse TNF-beta are 74% homologous and human and mouse LT-beta are 80% homologous.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LTBR
Entrez