Lymphotoxin beta R/TNFRSF3 Antibody (Carlos-1)

Images

 
Flow Cytometry: LTBR Antibody (Carlos-1) [NBP2-14824] HEK 293T cells (5x10^5) were mock transfected (thin line) or transfected with an expression plasmid enabling surface expression of the extracellular domain of human ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications Flow, IP
Clone
Carlos-1
Clonality
Monoclonal
Host
Rat
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

Lymphotoxin beta R/TNFRSF3 Antibody (Carlos-1) Summary

Immunogen
Recombinant human LTBR cysteine-rich region (aa 28-220).
Isotype
IgG1
Clonality
Monoclonal
Host
Rat
Gene
LTBR
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:1000
  • Immunoprecipitation 1:200

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Protein G purified

Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody (Carlos-1)

  • CD18
  • D12S370
  • ltbetar
  • LT-BETA-R
  • LTBR
  • lymphotoxin B receptor
  • Lymphotoxin beta R
  • lymphotoxin beta receptor (TNFR superfamily, member 3)
  • Lymphotoxin-beta receptor
  • LymphotoxinbR
  • TNF RIII
  • TNF Rrp
  • TNFCRTNF-RIII
  • TNFR superfamily, member 3
  • TNFR2-RP
  • TNFR3
  • TNF-R-III
  • TNFR-RP
  • TNFRSF3
  • TNFRSF3TNFR-III
  • Tumor necrosis factor C receptor
  • Tumor necrosis factor receptor 2-related protein
  • tumor necrosis factor receptor superfamily member 3
  • tumor necrosis factor receptor superfamily, member 3
  • Tumor necrosis factor receptor type III

Background

The LTBR activates two different NF-?B pathways that lead to distinct patterns of gene induction, including selected chemokines, and the cytokine BAFF, which is essential for the survival of mature B lymphocytes. LTBR activates the classical NF-?B (relA/p50) pathway, like the type 1 TNF receptor (TNFR1), that regulates proinflammatory genes, like the chemokine MIP1B. However, LTBR, unlike TNFR1, also activates the processing of p100 to form RelB/p52 complexes, which activate genes involved in lymphoid organ formation and lymphocyte survival.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol LTBR
Entrez
Uniprot