Lymphotoxin beta R/TNFRSF3 Antibody (31G4D8)

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Flow Cytometry: Lymphotoxin beta R/TNFRSF3 Antibody (31G4D8) [NB100-78050] - Human peripheral blood monocytes stained with purified 31G4D8, followed by biotinylated anti-mouse IgG and Sav-PE

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-78050
    • Availability
      Product Discontinued

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Lymphotoxin beta R/TNFRSF3 Antibody (31G4D8) Summary

Immunogen
Human Lymphotoxin-beta Receptor Fc protein
Specificity
The 31G4D8 antibody is specifc for human LT- betaR in flow cytometry, Western blot, immunoprepicitation and and ELISA (detection antibody). In addition, the 31G4D8 antibody is an agonistic antibody for the LT- betaR capable of inducing apoptosis, with IFN- gamma treatment (Chen, M-C., et al., 2003. J. Biol. Chem. 278:16073. )
Isotype
IgG2b Kappa
Clonality
Monoclonal
Host
Mouse
Gene
LTBR
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry < = 0.5 ug/10^6 cells in 100 ul
Application Notes
Additional reported applications include: Western blotting, immunoprecipitation, ELISA detection, induction of apoptosis.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody (31G4D8)

  • CD18
  • D12S370
  • ltbetar
  • LT-BETA-R
  • LTBR
  • lymphotoxin B receptor
  • Lymphotoxin beta R
  • lymphotoxin beta receptor (TNFR superfamily, member 3)
  • Lymphotoxin-beta receptor
  • LymphotoxinbR
  • TNF RIII
  • TNF Rrp
  • TNFCRTNF-RIII
  • TNFR superfamily, member 3
  • TNFR2-RP
  • TNFR3
  • TNF-R-III
  • TNFR-RP
  • TNFRSF3
  • TNFRSF3TNFR-III
  • Tumor necrosis factor C receptor
  • Tumor necrosis factor receptor 2-related protein
  • tumor necrosis factor receptor superfamily member 3
  • tumor necrosis factor receptor superfamily, member 3
  • Tumor necrosis factor receptor type III

Background

LTBR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LTBR is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LTBR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LTBR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LTBR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LTBR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LTBR
Entrez