Lymphotoxin beta R/TNFRSF3 Antibody (31G4D8) Summary
Human Lymphotoxin-beta Receptor Fc protein
The 31G4D8 antibody is specifc for human LT- betaR in flow cytometry, Western blot, immunoprepicitation and and ELISA (detection antibody). In addition, the 31G4D8 antibody is an agonistic antibody for the LT- betaR capable of inducing apoptosis, with IFN- gamma treatment (Chen, M-C., et al., 2003. J. Biol. Chem. 278:16073. )
Protein A or G purified
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Packaging, Storage & Formulations
Store at 4C. Do not freeze.
PBS [pH 7.2]
0.09% Sodium Azide
Protein A or G purified
Additional reported applications include: Western blotting, immunoprecipitation, ELISA detection, induction of apoptosis.
Alternate Names for Lymphotoxin beta R/TNFRSF3 Antibody (31G4D8)
- lymphotoxin B receptor
- lymphotoxin beta receptor (TNFR superfamily, member 3)
- Lymphotoxin-beta receptor
- TNF RIII
- TNF Rrp
- TNFR superfamily, member 3
- Tumor necrosis factor C receptor
- Tumor necrosis factor receptor 2-related protein
- tumor necrosis factor receptor superfamily member 3
- tumor necrosis factor receptor superfamily, member 3
- Tumor necrosis factor receptor type III
LTBR, also known as lymphotoxin beta receptor and tumor necrosis factor receptor superfamily member 3 is a 47 kD transmembrane protein containing 3 TNF receptor domains. The LTBR is a receptor for the heterotrimeric lymphotoxin complex (composed of LT alpha and LT beta as well as LIGHT. LTBR is highly expressed in the lung, liver, and kidney and moderately expressed expressed in the heart and testes. LTBR is weakly expressed in the brain, thymus, spleen, and lymph nodes. The cytoplasmic tail of LTBR interacts with TRAF3, TRAF4, and TRAF5 as well as the hepatitis C virus core protein. Ligand binding to LTBR has been shown to induce apoptosis (via TRAF3 and TRAF5) and play a role in the development of lymphoid organs.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed
for 1 year from date of receipt.
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