LPAR2/LPA2/EDG-4 Antibody

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Western Blot: LPAR2/LPA2/EDG-4 Antibody [NBP1-00792] - Lane1:HEK293T whole cell lysate. Lane2:Raw264.7 whole cell lysate. Lane3:PC12 whole cell lysate.
Western Blot: EDG4 Antibody [NBP1-00792] - Western blot (WB) analysis of EDG4 (Q330) antibody in extracts from COLO205 cells.

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-00792
    • Availability
      Product Discontinued

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LPAR2/LPA2/EDG-4 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 298-343 of Human EDG-4.
Specificity
EDG4 (Q330) detects endogenous levels of EDG-4 protein.
Clonality
Polyclonal
Host
Rabbit
Gene
LPAR2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:10-1:500
Application Notes
Western blot (WB) analysis of EDG4 (Q330) pAb in extracts from COLO205 cells.
Theoretical MW
39 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for LPAR2/LPA2/EDG-4 Antibody

  • EDG4
  • EDG-4
  • EDG4FLJ93869
  • endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor4,LPA receptor EDG4
  • G protein-coupled receptor
  • LPA2
  • LPA-2
  • LPA2LPA receptor 2
  • LPAR2
  • lysophosphatidic acid receptor 2
  • lysophosphatidic acid receptor EDG4
  • Lysophosphatidic acid receptor Edg-4

Background

The EDG (endothelial differentiation gene) family of G protein coupled receptors consists of eight family members that bind lysophospholipid (LPL) mediators, including sphingosine-1-phosphate (SPP) and lysophosphatidic acid (LPA). EDG-1, EDG-3, EDG-5 (also designated H218 and AGR16) and EDG-8 bind SPP with high-affinity. EDG-6 is a low-affinity receptor for SPP. LPA preferentially binds to EDG-2, EDG-4 and EDG-7. The EDG receptors couple to multiple G proteins to signal through Ras, MAP kinase, Rho, Phospholipase C or other tyrosine kinases, which lead to cell survival, growth, migration and differentiation. EDG-1 signals through Gi proteins to activate Akt and is expressed in glioma cells. EDG-2 is expressed in brain, especially in white matter tract regions, while EDG-3 is expressed in cardiovascular tissue and in cerebellum. EDG4 is highly expressed on leukocytes and brain, and EDG-5 has wide tissue distribution, including cardiovascular tissue and brain. Expressed in lymphoid and hematopoietic tissues and in lung, EDG-6 signals through Gi/o proteins, which activate growth related pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LPAR2
Entrez