Low Density LRP Antibody (alpha-2)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51778
    • Availability
      Product Discontinued

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Low Density LRP Antibody (alpha-2) Summary

Immunogen
Purified CD91
Specificity
Recognizes human CD91, a type I membrane protein which is also known as the alpha 2 macroglobulin receptor (alpha 2MR). Recognizes an epitope in the extracellular region of the 500kD alpha chain. Immunogen: Purified CD91
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LRP1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
The antibody can be used for flow cytometry, immunohistochemistry on frozen sections, ELISA (direct), immunoprecipitation and Western blotting (non-reducing).Flow cytometry: Use 10ul of the suggested working dilution (1:50-1:100) to label 106 cells or 100ul. Immunohistochemistry: Recommended positive control: Liver

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.4) and 1.0% BSA
Preservative
0.09% Sodium Azide
Concentration
1 mg/ml
Purity
Protein A or G purified

Notes

This product should be stored undiluted.

Alternate Names for Low Density LRP Antibody (alpha-2)

  • A2MRTGFBR5
  • Alpha-2-macroglobulin receptorMGC88725
  • APOER
  • Apolipoprotein E receptor
  • APR
  • CD91 antigen
  • CD91
  • EC 1.1.1.94
  • EC 3.4.21.9
  • FLJ16451
  • IGFBP3R
  • low density lipoprotein receptor-related protein 1
  • LRP
  • LRP-1
  • prolow-density lipoprotein receptor-related protein 1
  • TbetaR-V/LRP-1/IGFBP-3 receptor
  • type V tgf-beta receptor

Background

Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signaling, neuronal calcium signaling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 (alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LRP1