Low Density LRP Antibody (A2Mr alpha-2)

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Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, ELISA, Flow, IHC, IHC-Fr, IP
Clone
A2Mr alpha-2
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated
Concentration
1.0 mg/ml

Low Density LRP Antibody (A2Mr alpha-2) Summary

Immunogen
Purified alpha2 macroglobulin receptor
Specificity
Recognises an epitope in the extracellular region of the 500kD alpha chain.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
LRP1
Purity
Protein G purified
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Applications/Dilutions

Dilutions
  • Western Blot Non-reducing conditions
  • ELISA Direct
  • Flow Cytometry 1:50-1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • Immunoprecipitation 1:10-1:500
Application Notes
For Flow Cytometry: Use 10 ul of the suggested working dilution to label 10^6 cells in 100 ul. Use non-reducing conditions for western blot.
Positive Control
Low Density LRP Lysate (NBL1-12668)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
Phosphate buffered saline
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Protein G purified

Alternate Names for Low Density LRP Antibody (A2Mr alpha-2)

  • A2MRTGFBR5
  • Alpha-2-macroglobulin receptorMGC88725
  • APOER
  • Apolipoprotein E receptor
  • APR
  • CD91 antigen
  • CD91
  • EC 1.1.1.94
  • EC 3.4.21.9
  • FLJ16451
  • IGFBP3R
  • low density lipoprotein receptor-related protein 1
  • LRP
  • LRP-1
  • prolow-density lipoprotein receptor-related protein 1
  • TbetaR-V/LRP-1/IGFBP-3 receptor
  • type V tgf-beta receptor

Background

Low density lipoprotein receptor-related protein (also known as low density LRP, LRP1, alpha-2-macroglobulin receptor or Apolipoprotein E receptor) is an endocytotic receptor that is involved both in endocytosis and in phagocytosis of apoptotic cells. It is required for early embryonic development, is involved in cellular lipid homeostasis, and may play a role in APP metabolism, kinase-dependent intracellular signalling, neuronal calcium signalling and neurotransmission. Low density LRP also plays a role in the plasma clearance of chylomicron remnants and activated LRPAP1 alpha-2-macroglobulin), and is involved in the local metabolism of complexes of plasminogen activators and their endogenous ligands. Low density LPR is postulated to be one of the major players in host resistance to HIV. The precursor low density LRP molecule is cleaved post-translationally to form a 85 kDa membrane-spanning subunit (LRP-85) and a 515 kDa large extracellular domain (LRP-515), which remains non-covalently associated with LRP-85. Following cleavage, the intracellular domain (LPRICD) is present in both the cytoplasm and the nucleus.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol LRP1