LKB1/STK11 [p Ser428] Antibody

Product Discontinued

LKB1/STK11 [p Ser428] Antibody Summary

• Immunogen: Synthetic phosphopeptide derived from human LKB1 around the phosphorylation site of Serine 428.
• Modification: p Ser428
• Clonality: Polyclonal
• Host: Rabbit
• Gene: STK11
• Purity: Immunogen affinity purified

Applications/Dilutions

• Dilutions:
  • Immunocytochemistry/ Immunofluorescence 1:50-1:200
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:50-1:200
  • Western Blot 1:500-1:1000
• Application Notes: Western blot (WB) analysis of p-LKB1 (S428) pAb in extracts from CV-1 forsklin cells .
  Immunohistochemistry (IHC) analyzes of p-LKB1 (S428) pAb in paraffin-embedded human breast carcinoma tissue.
• Theoretical MW: 54 kDa.
  Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: PBS (approx. pH 7.2)
• Preservative: 0.05% Sodium Azide
• Concentration: 1.0 mg/ml
• Purity: Immunogen affinity purified

Alternate Names for LKB1/STK11 [p Ser428] Antibody

• EC 2.7.11.1
• LKB1 serine/threonine kinase 11 (Peutz-Jeghers syndrome)
• LKB1
• PJS polarization-related protein LKB1
• PJS
• Renal carcinoma antigen NY-REN-19
• serine/threonine kinase 11
• serine/threonine-protein kinase 11
• Serine/threonine-protein kinase LKB1
• STK11

Background

Peutz-Jeghers syndrome (PJS) is a rare hereditary disease characterized by melanocytic macules lips, gastrointestinal hamartomatous polyps and an increased risk for many classes of cancer. LKB1 (also designated STK11 and PJS) has been identified as the gene mutated in PJS. LKB1 is a 433 amino acid Serine/Threonine kinase with strong homology to the Xenopus cytoplasmic protein kinase XEEK1 and weaker similarity to many other protein kinases. LKB1 is ubiquitously expressed and many frameshift, deletion and splicing mutations have been identified in PJS patients. Despite the increased risk of cancer for PJS patients, LKB1 does not appear to play a major role in colorectal, testicular or breast cancers.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: STK11
• Entrez:
  • 6794(Human)
• Uniprot:
  • Q15831()