Lgl1 Antibody (4D11) [FITC]

Images

 
Flow Cytometry: Lgl1 Antibody (4D11) [FITC] [NBP2-00294] - Staining of C57BL/6 splenocytes with Anti-Mouse CD49b (Integrin alpha 2) PE and 0.125 ug of Rat IgG2a kappa Isotype Control FITC (NBP1-43959) (left) or 0.125 ug ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-00294
    • Availability
      Product Discontinued

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Lgl1 Antibody (4D11) [FITC] Summary

Immunogen
The immunogen for this antibody is LGL1.
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
LLGL1
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
This 4D11 (4D11) antibody has been tested by flow cytometric analysis of mouse splenocytes. This can be used at less than or equal to 1.0 ug per test. A test is defined as the amount (ug) of antibody that will stain a cell sample in a final volume of 100 uL. Cell number should be determined empirically but can range from 10^5 to 10^8 cells/test. This 4D11 antibody has also been reported for use in immunoprecipitation. It is recommended that the antibody be carefully titrated for optimal performance in the assay of interest.

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Lgl1 Antibody (4D11) [FITC]

  • DLG4lethal giant larvae (Drosophila) homolog 1
  • HUGL
  • HUGL1
  • HUGL-1
  • Human homolog to the D-lgl gene protein
  • lethal giant larvae homolog 1 (Drosophila)
  • lethal(2) giant larvae protein homolog 1
  • LLGL

Background

The 4D11 monoclonal antibody reacts with Ly-49G2 (also known as LGL-1). The Ly-49 family of NK-cell receptors, members of the C-type lectin superfamily, are disulfide-linked type-II transmembrane protein homodimers with extracellular carbohydrate recognition domains, which bind to MHC class I alloantigens. The Ly-49 family members are expressed independently, such that an individual NK or T cell may display more than one class of Ly-49 receptor. Ly-49G2 is an inhibitory receptor expressed on subsets of natural killer (NK) cells, NK-T cells (in all strains tested), and on a population of memory CD8+ T cells (in C57BL/6 mice). The 4D11 antibody has been reported to cross react with the Ly-49AB6, Ly-49ABALB, and Ly-49T129/J inhibitory receptors and Ly-49LCBA/J activating receptors. The proportion of NK-T cells expressing Ly-49A and Ly-49G2 is higher in the thymus than in liver, and there is evidence that down-regulation of Ly-49 receptor expression is necessary for normal NK-T-cell development to occur.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol LLGL1