Leptin/OB Recombinant Protein

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Product Details

Summary
Reactivity HuSpecies Glossary
Concentration
Lyoph

Order Details

Leptin/OB Recombinant Protein Summary

Description
A recombinant protein corresponding to 146 amino acids of Human Leptin/OB

Source: E. coli

Amino Acid Sequence: The amino acid sequence of this product is not available.
Preparation
Method
E. coli
Details of Functionality
Human Leptin has been shown to be biologically active in two different mouse obesity models, ob/ob and NZO. Both strains of mice were treated via intraperitoneal injection once daily at a dose of 5 mg Leptin/gm of body weight for 7 days. Significant effects on body weight, food consumption, and plasma glucose levels were observed to saline-treated controls.
Gene
LEP
Endotoxin Note
<0.1 ng/ug

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Conjugate
Unconjugated
Buffer
Sterile filtered
Concentration
Lyoph
Reconstitution Instructions
Centrifuge prior to opening. Reconstitute with 3 mM Acetic acid to a final concentration of 5 - 10 mg/ml.

Notes

The purity of this protein is >95% pure by SDS-PAGE

Alternate Names for Leptin/OB Recombinant Protein

  • FLJ94114
  • LEP
  • leptin (murine obesity homolog)
  • leptin (obesity homolog, mouse)
  • leptin
  • Leptin/OB
  • OB
  • Obese protein
  • obese, mouse, homolog of
  • Obesity factor
  • OBOBS

Background

Leptin (Anti-Obesity Protein) is the protein product of the ob (obese) gene in mice and seems to be involved in appetite control. The ob gene is expressed in adipose tissue and is thought to regulate the body's fat stores. Mice with the ob/ob genotype also develop a form of diabetes similar to type II (non-insulin dependent) diabetes. Human Leptin is a 16 kDa protein containing 146 amino acid residues.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol LEP
Entrez
Uniprot

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