LDL R Antibody

Images

 
Western Blot: LDL R Antibody [NBP1-77029] - Human liver tissue lysate with LDL-R antibody at (A) 1 and (B) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: LDL R Antibody [NBP1-77029] - Immunofluorescence of LDLR in human liver tissue with LDLR antibody at 20 ug/mL.
Immunohistochemistry-Paraffin: LDL R Antibody [NBP1-77029] - Human liver tissue with LDL-R antibody at 2.5 ug/ml.

Product Details

Summary
Reactivity Hu, Mu, RtSpecies Glossary
Applications WB, ELISA, ICC/IF, IHC, IHC-P
Clonality
Polyclonal
Host
Chicken
Conjugate
Unconjugated
Concentration
1 mg/ml

Order Details

LDL R Antibody Summary

Immunogen
Antibody was raised against an 18 amino acid synthetic peptide near the center of human LDL-R. The immunogen is located within amino acids 490 - 540 of LDL-R.
Isotype
IgY
Clonality
Polyclonal
Host
Chicken
Gene
LDLR
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1-2 ug/ml
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 20 ug/ml
  • Immunohistochemistry 2.5 ug/ml
  • Immunohistochemistry-Paraffin 2.5 ug/ml
Positive Control
Liver Lysate (NB820-59232)
Control Peptide
LDL R Peptide (NBP1-77029PEP)

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for LDL R Antibody

  • FH
  • FHC
  • LDL R
  • LDL receptor
  • LDLCQ2
  • LDLR
  • low density lipoprotein receptor
  • low-density lipoprotein receptor class A domain-containing protein 3
  • low-density lipoprotein receptor

Background

The low density lipoprotein receptor (LDL-R) gene family consists of cell surface proteins involved in receptor-mediated endocytosis of specific ligands. Low density lipoprotein (LDL) is normally bound at the cell membrane and taken into the cell ending up in lysosomes where the protein is degraded and the cholesterol is made available for repression of microsomal enzyme 3-hydroxy-3-methylglutaryl coenzyme A (HMG CoA) reductase, the rate-limiting step in cholesterol synthesis. At the same time, a reciprocal stimulation of cholesterol ester synthesis takes place. Mutations in the LDL-R gene cause the autosomal dominant disorder, familial hypercholesterolemia. Along with SCARB1, CLDN1, and the tetraspanin superfamily member CD81, LDL-R has been reported to be an entry factor for the Hepatitis C virus. At least three isoforms of LDL-R are known to exist.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for LDL R Antibody (NBP1-77029) (0)

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics

Gene Symbol LDLR
Entrez
Uniprot