LDL R Antibody (C7) [DyLight 488]

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Product Details

Summary
Reactivity Hu, Rt, Po, BvSpecies Glossary
Applications WB, ELISA, Flow, ICC/IF, IHC-Fr, IHC-P
Clone
C7
Clonality
Monoclonal
Host
Mouse
Conjugate
DyLight 488

LDL R Antibody (C7) [DyLight 488] Summary

Immunogen
Partially purified bovine LDL receptor [Swiss-Prot# P01131]
Localization
Cell membrane/cell surface, endomembrane system, endosomes, lysosome, clathrin-coated pit, and Golgi apparatus
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
LDLR
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This LDL Receptor (C7) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin embedded section, Immunoprecipitation and Western blot, where bands can be seen around 160 kDa (mature form) and 120 kDa (precursor). Radioimmunoassay and ELISA were reported in scientific literature.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries. This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LDL R Antibody (C7) [DyLight 488]

  • FH
  • FHC
  • LDL R
  • LDL receptor
  • LDLCQ2
  • LDLR
  • low density lipoprotein receptor
  • low-density lipoprotein receptor class A domain-containing protein 3
  • low-density lipoprotein receptor

Background

In cholesterol homeostasis regulation, the low density lipoprotein receptor is a critical factor. LDLR binds and internalizes LDL, then directs LDL toward cellular synthetic machinery, or towards destructive pathways for release or recycling. When alternatively spliced forms of the LDLR are present in cells, its native enzymatic activity is often reduced. This reduction in enzyme function is often related to the formation of atherosclerotic plaques. A common Class 5 mutation in LDLR results in it being able to bind and internalize LDL, but subsequently unable to release it to endosomes for recycling. LDLR is dependent upon the activity of PCSK9 for regulating its activity. In the liver, the LDLR is degraded when signaled by PCSK9, which increases the probability of high hepatic levels of LDL. In the brain, PCSK9 downregulates LDLR levels during development and following adult brain injury, thus demonstrating the dual functionality of this critical receptor.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for LDL R Antibody (NBP1-78159G) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP1-78159APC
Biotin Labeled NBP1-78159B
DyLight 350 Labeled NBP1-78159UV
DyLight 405 Labeled NBP1-78159V
DyLight 550 Labeled NBP1-78159R
DyLight 650 Labeled NBP1-78159C
DyLight 680 Labeled NBP1-78159FR
DyLight 755 Labeled NBP1-78159IR
FITC Labeled NBP1-78159F
HRP Labeled NBP1-78159H
PE Labeled NBP1-78159PE

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Bioinformatics Tool for LDL R Antibody (NBP1-78159G)

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Calculators

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Bioinformatics

Gene Symbol LDLR
Entrez