LDL R Antibody (C7) [FITC]

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Product Details

Summary
Reactivity Hu, Rt, Po, BvSpecies Glossary
Applications ELISA, Flow, ICC/IF, IHC-Fr, IHC-P
Clone
C7
Clonality
Monoclonal
Host
Mouse
Conjugate
FITC

LDL R Antibody (C7) [FITC] Summary

Immunogen
Partially purified bovine LDL receptor [Swiss-Prot# P01131]
Localization
Cell membrane/cell surface, endomembrane system, endosomes, lysosome, clathrin-coated pit, and Golgi apparatus
Isotype
IgG2b
Clonality
Monoclonal
Host
Mouse
Gene
LDLR
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA
  • Flow Cytometry
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry-Frozen
  • Immunohistochemistry-Paraffin
Application Notes
This LDL Receptor (C7) antibody is useful for Immunocytochemistry/Immunofluorescence, Immunohistochemistry on paraffin embedded section, Immunoprecipitation and Western blot, where bands can be seen around 160 kDa (mature form) and 120 kDa (precursor). Radioimmunoassay and ELISA were reported in scientific literature.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
PBS
Preservative
0.05% Sodium Azide
Purity
Protein G purified

Notes

This conjugate is made on demand. Actual recovery may vary from the stated volume of this product. The volume will be greater than or equal to the unit size stated on the datasheet.

Alternate Names for LDL R Antibody (C7) [FITC]

  • FH
  • FHC
  • LDL R
  • LDL receptor
  • LDLCQ2
  • LDLR
  • low density lipoprotein receptor
  • low-density lipoprotein receptor class A domain-containing protein 3
  • low-density lipoprotein receptor

Background

LDL Receptor (low-density lipoprotein receptor or LDLR) is a key determinant of plasma cholesterol levels and as a ubiquitously expressed cell membrane glycoprotein, it binds LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells via endocytosis. LDLR is found distributed from plasma membrane to intracellular compartments, cell surface (in the presence of PCSK9) and also localizes to Golgi apparatus as well as early/late endosomes and lysosomes. VLDL, IDL, HDL, and chylomicron remnant are also recognized by LDLR at neutral pH. Receptor-ligand complexes undergo endocytosis via clathrin-coated pits and coated vehicle dispenses to endosomes with LRP6 and ARH (also known as LDLR adaptor protein), connecting LDLR family protein and the endocytic machinery; thereby, acidic condition activates dissociation of internalized ligands. Released ligand particles further travel to lysosomes wherein the ligand is degraded by enzyme, while the receptors recycle back to cell surface. After internalization, LDL particles trigger reduction in HMGCR expression to suppress cholesterol biosynthesis; enhancement of ACAT activity to reduce toxic free cholesterol, and suppression of LDLR synthesis to reduce LDL uptake via SREBPs. Genetic mutations impairing LDLR function results in a condition with extremely elevated serum LDL levels and early onset atherosclerosis known as familial hypercholesterolemia (FH).

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

Video Protocols

ICC/IF Video Protocol

FAQs for LDL R Antibody (NBP1-78159F) (0)

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Secondary Antibodies

 

Isotype Controls

Other Available Formats

Allophycocyanin Labeled NBP1-78159APC
Biotin Labeled NBP1-78159B
DyLight 350 Labeled NBP1-78159UV
DyLight 405 Labeled NBP1-78159V
DyLight 488 Labeled NBP1-78159G
DyLight 550 Labeled NBP1-78159R
DyLight 650 Labeled NBP1-78159C
DyLight 680 Labeled NBP1-78159FR
DyLight 755 Labeled NBP1-78159IR
HRP Labeled NBP1-78159H
PE Labeled NBP1-78159PE

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Bioinformatics

Gene Symbol LDLR
Entrez