LC3C Antibody

Product Discontinued

LC3C Antibody Summary

• Immunogen: A synthetic peptide as a part of human microtubule-associated protein 1 light chain 3 gamma (MAP1LC3C, MAP1A/MAP1B LC3 C) conjugated to immunogenic carrier protein has been used as the immunogen.
• Clonality: Polyclonal
• Host: Sheep
• Gene: MAP1LC3C
• Purity: Unpurified

Applications/Dilutions

• Dilutions:
  • Immunohistochemistry 1:200-1:5000
  • Western Blot 1:200-1:5000

Packaging, Storage & Formulations

• Storage: Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
• Buffer: Whole antisera
• Preservative: No Preservative
• Concentration: LYOPH
• Purity: Unpurified
• Reconstitution Instructions: Reconstitute with 0.1 ml sterilized water to desired concentration.

Alternate Names for LC3C Antibody

• ATG8J
• Autophagy-related protein LC3 C
• Autophagy-related ubiquitin-like modifier LC3 C
• LC3C
• LC3-like protein 2
• MAP1 light chain 3-like protein 2
• MAP1 light chain 3-like protein 3
• MAP1A/MAP1B LC3 C
• microtubule-associated protein 1 light chain 3 gammaMAP1A/MAP1B light chain 3 C
• microtubule-associated proteins 1A/1B light chain 3C

Background

Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. FUNCTION: Probably involved in formation of autophagosomal vacuoles (autophagosomes). SUBUNIT: 3 different light chains, LC1, LC2 and LC3, can associate with MAP1A and MAP1B proteins. SUBCELLULAR LOCATION: Cytoplasm. Intracytoplasmic membrane; Lipid-anchor. Cytoplasmic vesicle, autophagosome membrane; Lipid-anchor. Note: LC3-II binds to the autophagic membranes. TISSUE SPECIFICITY: Most abundant in placenta, lung and ovary. The precursor molecule is cleaved by APG4B/ATG4B to form the cytosolic form, LC3-I. This is activated by APG7L/ATG7, transferred to ATG3 and conjugated to phospholipid to form the membrane-bound form, LC3-II.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Bioinformatics

• Gene Symbol: MAP1LC3C
• Entrez:
  • 440738(Human)
• Uniprot:
  • Q9BXW4(Human)