LC3 Antibody Pack

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Product Details

Summary
Concentration
Concentration of individual antibodies may be found on the vial label. If unlisted please contact technical services.

Order Details

LC3 Antibody Pack Summary

Gene
MAP1LC3B

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Concentration
Concentration of individual antibodies may be found on the vial label. If unlisted please contact technical services.

Kit Components

Alternate Names for LC3 Antibody Pack

  • ATG8F
  • LC3B
  • MAP1A/1BLC3
  • map1lc3b
  • MAP1LC3B-a
  • microtubule associated protein 1 light chain 3 beta

Background

Autophagy is a process of intracellular bulk degradation in which cytoplasmic components, including organelles, are sequestered within double-membrane vesicles that deliver the contents to the lysosome/vacuole for degradation. During macroautophagy, the sequestering vesicles, termed autophagosomes, fuse with the lysosome or vacuole resulting in the delivery of an inner vesicle (autophagic body) into the lumen of the degradative compartment. There are 16 proteins participating in the autophagy pathway in human. The autophagy protein LC3, a mammalian homologue of Atg8, was originally identified as microtubule-associated protein 1 light chain 3. It is a component of both the MAP1A and MAP1B microtubule-binding domains and the heavy-chain independent regulation of LC3 expression might modify MAP1 microtubule-binding activity during development. LC3 is the only known mammalian protein identified that stably associate with the autophagosome membranes. LC3-I is cytosolic and LC3-II is membrane bound and enriched in the autophagic vacuole fraction. The detection of LC3-I to LC3-II conversion is a useful and sensitive marker for distinguishing autophagy in mammalian cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Antibody Packs are guaranteed for 1 year from date of receipt.

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    Blogs on LC3. Showing 1-10 of 39 blog posts - Show all blog posts.

    Optogenetic Control of Mitophagy: AMBRA1 based mitophagy switch
    By Christina Towers, PhD Mitophagy in the BrainSelective autophagic degradation of damaged mitochondria, known as mitophagy, has been described as a cyto-protective process. Accordingly, defects in mitophagy have be...  Read full blog post.

    Autophagic flux: Is p62 a good indicator?
    By Christina Towers, PhD Is p62 a good indicator of autophagic flux? The short answer: Yes … but … SQSTM1 encodes the cargo adaptor protein, p62, which interacts with autophagic substrates and delivers them to autopha...  Read full blog post.


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    Microglia: pruning shears for homeostatic maintenance in the brain
    By Jennifer Sokolowski, MD, PhD.Microglia play a critical role in pruning neurons and synapses during homeostatic maintenance in the adult brain.1 A recent study by Ayata et al. (2018) identified regional differe...  Read full blog post.


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    Best way to quantitatively measure Autophagic Flux
    By Christina Towers, PhD Autophagy is a stress induced cellular recycling process that plays an important physiological role in many diseases. It is induced by a variety of stimuli both intracellular and extracellula...  Read full blog post.

    Best Methods to Induce and Inhibit Autophagy Pharmacologically
    By Christina Towers, PhD Autophagy facilitates the degradation and recycling of damaged cytoplasmic material. The multistep process consists of a double membrane structure called an autophagosome that engulfs proteins...  Read full blog post.

    RNA-binding protein Staufen1 conspires with Atxn2 in stress granules to cause neurodegeneration by dysregulating RNA metabolism
    By Jamshed Arslan Pharm.D. Spinocerebellar ataxia type 2 (SCA2) is a movement disorder characterized by neurodegeneration. The cause of this autosomal dominant disease is a mutation in the RNA processing gene Atxn2,...  Read full blog post.

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    Bioinformatics

    Gene Symbol MAP1LC3B