Latent TGF-beta bp2/LTBP-2 Antibody (327318) [Alexa Fluor® 647]

• Reactivity: Hu
• Applications: WB
• Clone: 327318
• Clonality: Monoclonal
• Host: Mouse
• Conjugate: Alexa Fluor 647

Latent TGF-beta bp2/LTBP-2 Antibody (327318) [Alexa Fluor® 647] Summary

• Immunogen: Mouse myeloma cell line NS0-derived recombinant human Latent TGF‑β bp2/LTBP‑2
  Gln36-Glu1821
  Accession # NP_000419
• Specificity: Detects human Latent TGF‑ beta bp2/LTBP‑2 in direct ELISAs and Western blots. In direct ELISAs and Western blots, no cross-reactivity with recombinant mouse LTMP-4 is observed.
• Isotype: IgG2b
• Clonality: Monoclonal
• Host: Mouse
• Purity Statement: Protein A or G purified

Applications/Dilutions

• Dilutions:
  • Western Blot

Packaging, Storage & Formulations

• Storage: Protect from light. Do not freeze. 12 months from date of receipt, 2 to 8 °C as supplied
• Buffer: Supplied 0.2mg/ml in 1X PBS with RDF1 and 0.09% Sodium Azide

Notes

This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.

Alternate Names for Latent TGF-beta bp2/LTBP-2 Antibody (327318) [Alexa Fluor® 647]

• C14orf141
• GLC3D
• Latent TGFbeta bp2
• Latent TGF-beta bp2
• latent transforming growth factor beta binding protein 2
• latent-transforming growth factor beta-binding protein 2
• LTBP2
• LTBP-2
• LTBP3chromosome 14 open reading frame 141
• MSTP031

Background

LTBP-2 is a 240 kDa member of the LTBP and fibrillin families. Unlike other LTBP, LTBP-2 is not a component of the large latent TGF-beta complex. LTBP-2 is a secreted calcium-binding extracellular matrix glycoprotein of elastic tissue 10 nm microfibrils, especially in the lung. The 1786 aa mature human LTBP2 contains 20 EGF‑like domains and four 8-cysteine repeats and shares 80% aa identity with mouse LTBP-2. An RGD sequence and a proline-rich sequence may mediate adhesion of melanoma cells, but for fibroblasts LTBP-2 may actually be an antiadhesion protein. In vivo, proteolysis by plasmin and elastase is likely and may cleave putative adhesion sites.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.