LAT Antibody

Images

 
Western Blot: LAT Antibody [NBP1-51323] - Analysis of LAT (D156) pAb in extracts from Jurkat cells.

Product Details

Summary
Product Discontinued
View other related LAT Primary Antibodies

Order Details


    • Catalog Number
      NBP1-51323
    • Availability
      Product Discontinued

    Can't find what you are looking for? Use our Antibody Concierge Service & we will help you locate your antibody!

    Or feel free to contact us for alternative products.

LAT Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 131-180 of Human LAT.
Specificity
LAT (D156) pAb detects endogenous levels of LAT protein.
Clonality
Polyclonal
Host
Rabbit
Gene
LAT
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of LAT (D156) pAb in extracts from Jurkat cells.
Theoretical MW
38 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (approx. pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for LAT Antibody

  • 36 kDa phospho-tyrosine adapter protein
  • LAT
  • LAT1,36 kDa phospho-tyrosine adaptor protein
  • linker for activation of T cells
  • linker for activation of T-cells family member 1
  • p36-38
  • pp36

Background

LAT, a transmembrane adaptor protein expressed in T, NK and mast cells, is an important mediator for T cell receptor (TCR) signaling. Upon TCR engagement, activated Zap-70 phosphorylates LAT at multiple conserved tyrosine residues within SH2 binding motifs, exposing these motifs as the docking sites for downstream signaling targets. The phosphorylation of LAT at Tyr171 and 191 enables the binding of Grb2, Gads/SLP-76, PLCgamma1 and PI3 kinase through their SH2 domain and translocates them to the membrane. This process eventually leads to activation of the corresponding signaling pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

Customers Who Viewed This Item Also Viewed...

NB110-60490
Species: Hu
Applications: WB, ELISA, IHC, IHC-P
MAB4066
Species: Hu
Applications: WB, CyTOF-ready, ICFlow
MAB7474
Species: Hu
Applications: WB, Simple Western, ICC
NBP1-47989
Species: Hu
Applications: WB, IHC, IHC-P
NBP2-36491
Species: Hu
Applications: WB, Flow, IHC, IHC-P, Flow-CS
NBP2-00764
Species: Hu
Applications: WB, Flow, IHC, IHC-P
NBP1-32945
Species: Hu, Mu, Rt
Applications: WB, ICC/IF, IHC, IHC-P, IP
NBP2-50465
Species: Hu
Applications: Flow, IHC, CyTOF-ready, Flow-CS
MAB7500
Species: Hu
Applications: WB, ICC
MAB38461
Species: Hu
Applications: WB, IHC
AF2685
Species: Hu
Applications: WB, Simple Western, IHC
NBP2-24867
Species: Hu, Mu
Applications: Flow, Func, In vitro, In vivo, CyTOF-ready, Flow-CS
MAB37861
Species: Hu
Applications: WB, Simple Western, ICC
NBP1-19371
Species: Hu, Mu, Rt, Ca, Rb
Applications: WB, Simple Western, ICC/IF, IHC, IHC-P
AF467
Species: Hu, Mu
Applications: WB, Simple Western, Flow, IHC, CyTOF-ready, ICC
AF-386-PB
Species: Hu
Applications: WB, Flow, CyTOF-ready, ICC
NBP1-51323
Species: Hu
Applications: WB

Publications for LAT Antibody (NBP1-51323) (0)

There are no publications for LAT Antibody (NBP1-51323).
By submitting your publication information earn gift cards and discounts for future purchases.

Reviews for LAT Antibody (NBP1-51323) (0)

There are no reviews for LAT Antibody (NBP1-51323). By submitting a review you will receive an Amazon e-Gift Card or Novus Product Discount.
  • Review with no image -- $10/€7/£6/$10 CAD/¥70 Yuan/¥1110 Yen
  • Review with an image -- $25/€18/£15/$25 CAD/¥150 Yuan/¥2500 Yen
  • 1st to review with an image -- $50/€35/£30/$50 CAD/¥300 Yuan/¥5000 Yen

Product General Protocols

Find general support by application which include: protocols, troubleshooting, illustrated assays, videos and webinars.

Video Protocols

WB Video Protocol

FAQs for LAT Antibody (NBP1-51323) (0)

There are no specific FAQs related to this product. Read our general customer & technical service FAQs.

Secondary Antibodies

 

Isotype Controls

Additional LAT Products

Bioinformatics Tool for LAT Antibody (NBP1-51323)

Discover related pathways, diseases and genes to LAT Antibody (NBP1-51323). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
Visit Tool

Diseases for LAT Antibody (NBP1-51323)

Discover more about diseases related to LAT Antibody (NBP1-51323).
 

Pathways for LAT Antibody (NBP1-51323)

View related products by pathway.

PTMs for LAT Antibody (NBP1-51323)

Learn more about PTMs related to LAT Antibody (NBP1-51323).
 

Research Areas for LAT Antibody (NBP1-51323)

Find related products by research area.

Blogs on LAT.

CD3 (OKT3) as a marker of immune response efficiency
Our immune system is a powerful defense mechanism against infection, however different variables can cause our immune response to work for or against us.  CD3 (cluster of differentiation 3) is one component of our immune signal response that is co...  Read full blog post.

Contact Information

Product PDFs

Calculators

Concentration Calculator

The concentration calculator allows you to quickly calculate the volume, mass or concentration of your vial. Simply enter your mass, volume, or concentration values for your reagent and the calculator will determine the rest.

=
÷

Review this Product

Be the first to review our LAT Antibody and receive a gift card or discount.

Bioinformatics

Gene Symbol LAT
Entrez