Laminin gamma 1 Antibody (BC17)



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Laminin gamma 1 Antibody (BC17) Summary

The antibody reacts with Human Laminin gamma 1.
The antibody recognizes the Mr 200,000 g1-chain of human reduced and alkylated laminin produced by various cultured cells, which produce laminins complexed with it. The specificity of Mab BC17 has been confirmed by immunoprecipitation and Elisa by using recombinant g1- chain. The antibody only reacts with human cells and tissues (further studies are going on). Laminin, a major structural glycoprotein of the basement membranes, is an attachment and survival factor for epithelial cells and can also promote the growth of epithelial cells. Laminin plays an important role in both the structural organization of basement membranes and in the anchorage of cells. The monoclonal antibody, DG10 and BC17 against laminin chain beta 1 and g1, respectively can be widely applied in immunohistochemical studies as all basement membranes contain laminin trimers containing these chains. Antibodies to laminin chains are useful in basic biology studies as well as in pathological studies concerning, for instance, the integrity of the basement membranes in carcinomas. Clone DG 10 against laminin beta 1-chain is apparently one of the few laminin antibodies working perfectly in immunoblotting, thus making it especially valuable for biochemical studies. Monoclonal antibody (Mab) to laminin g1-chain is derived from the hybridoma produced by fusion between myeloma cells and Balb/c spleen cells. Pepsin-digested laminins from human placenta were used as immunogen.
Protein A or G purified
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Packaging, Storage & Formulations

Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
100 mg immunoglobulin in 1 ml PBS solution containing 1.0% (w/v) BSA
0.1% Sodium Azide
Please see the vial label for concentration. If unlisted please contact technical services.
Protein A or G purified


Application Notes
Immunohistochemical stainings on frozen sections and immunoprecipitation. Does not work in western blotting.

Reactivity Notes



Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the gamma chain isoform laminin, gamma 1. The gamma 1 chain, formerly thought to be a beta chain, contains structural domains similar to beta chains, however, lacks the short alpha region separating domains I and II. The structural organization of this gene also suggested that it had diverged considerably from the beta chain genes. Embryos of transgenic mice in which both alleles of the gamma 1 chain gene were inactivated by homologous recombination, lacked basement membranes, indicating that laminin, gamma 1 chain is necessary for laminin heterotrimer assembly. It has been inferred by analogy with the strikingly similar 3' UTR sequence in mouse laminin gamma 1 cDNA, that multiple polyadenylation sites are utilized in human to generate the 2 different sized mRNAs (5.5 and 7.5 kb) seen on Northern analysis.


This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Gene Symbol LAMC1

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