The lamins form a meshwork of filaments on the inner, or nucleoplasmic, surface of the nuclear envelope. Currently, mammalian species appear to contain at least four major lamins, called A, B1, B2, and C, of which two (A and C) arise by alternative splicing of the same gene and two minor lamins, D and E, whose molecular weight varies from species to species. Nuclei of embryonic and lymphiod cells contain only lamin B1. Mutations affecting A-type lamins have been associated with a variety of human diseases, including muscular dystrophy, cardiomyopathy, lipodystrophy, and progeria, but mutations in B-type lamins have never been identified in humans. Homozygous lamin B1 mutant mice survive embryonic development but died at birth with defects in lung and bone. Cells obtained from mutant lamin B1 mice are defective in differentiation, polyploidy and senesce prematurely.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.
FAQs for Lamin B1 Antibody (NB100-56403). (Showing 1 - 1 of 1 FAQs).
I'm looking for human lamin antibodies that might cross react with Drosophila lamins. I've found a few that I'm interested in, one of which comes in a smaller sample size. The other two do not have a smaller size ordering option. I was wondering if it would be possible to get these other antibodies in a smaller size as well, so we can test reactivity with Drosophila lamins before ordering the full-sized product?
We have a wide range of antibodies to human Lamin. Unfortunately none of these has yet been tested against Drosophila samples, however you may be interested in our Innovator's Reward Program. This allows you to try our primary antibodies in an untested species or application, without the financial risk of failure. To participate you simply complete an online review with an image, detailing the positive or negative results of your study, and in return you receive a discount voucher for 100% of the purchase price of the reviewed product. We are unable to offer free samples of our antibodies but, as you rightly point out, some are available as smaller, sample size aliquots. If a sample size is not listed for a product I am afraid we are unable to offer a smaller aliquot than those already listed.