Lambda5/IGLL1 Antibody

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Western Blot: IGLL1 Antibody [NBP1-51207] - Extracts from HeLa cells

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-51207
    • Availability
      Product Discontinued

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Lambda5/IGLL1 Antibody Summary

Immunogen
Synthetic peptide, corresponding to the N-terminus of Human CD179b.
Specificity
CD179b (V26) pAb detects endogenous levels of CD179b protein.
Clonality
Polyclonal
Host
Rabbit
Gene
IGLL1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
Application Notes
Western blot (WB) analysis of CD179b (V26) pAb in extracts from HeLa cells
Theoretical MW
25 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (approx. pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Lambda5/IGLL1 Antibody

  • 14.1
  • AGM2
  • CD179 antigen-like family member B
  • CD179b antigen
  • CD179b
  • Ig lambda-5
  • IGL1
  • IGL5
  • IGL5CD179B
  • IGLJ14.1
  • IGLL
  • IGLL1
  • IGO
  • IGVPB
  • immunoglobulin lambda-like polypeptide 1
  • immunoglobulin omega polypeptide chain
  • Immunoglobulin omega polypeptide
  • immunoglobulin-related 14.1 protein
  • Immunoglobulin-related protein 14.1
  • Lambda5
  • Pre-B lymphocyte-specific protein-2
  • VPREB2

Background

Lambda 5 (also called immunoglobulin lambda-like polypeptide 1 or CD179b antigen) and VpreB comprise the surrogate light chain of the pre-B cell receptor complex. SL chain is also part of a quality control mechanism that tests a u-chain for its ability to pair with conventional L chains. It can form Ig-like complexes with the heavy (H) chain, the DHJHC u-protein or the p55 chain. Production of the surrogate light chain begins at the stage of pro-B cells, continues during the pre-B cell stage and halts at the immature B cell stage. Once pre-BCR is expressed, SL chain expression is turned off. As pre-B II cells proliferate, SL is diluted out, thus limiting pre-BCR formation. Lambda 5, a 22 kDa protein, is critical for B cell development in mammals. Expression of Lambda 5 is highest in liver, pre-B lymphocytes and bone marrow, the major source of B cell precursors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol IGLL1
Entrez