Laforin/EPM2A Antibody

Images

 
Western Blot: Laforin/EPM2A Antibody [NBP1-18846] - Analysis of Laforin (isoform a) in Human Cerebellum lysate (35ug protein in RIPA buffer) using this antibody at 0.1 ug/ml. Primary incubation was 1 hour. Detected by ...read more
Immunohistochemistry-Paraffin: Laforin/EPM2A Antibody [NBP1-18846] - Staining of paraffin embedded Human Cerebellum using this antibody at 3.8 ug/ml. Steamed antigen retrieval with citrate buffer pH 6, AP-staining.

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, IHC, IHC-P, PEP-ELISA
Clonality
Polyclonal
Host
Goat
Conjugate
Unconjugated
Concentration
0.5 mg/ml

Order Details

Laforin/EPM2A Antibody Summary

Immunogen
Peptide with sequence C-EATGHTNEMKHTTD corresponding to internal region according to NP_005661.1.
Epitope
internal region
Specificity
This antibody is expected to recognize isoform a (NP_005661.1) only.
Isotype
IgG
Clonality
Polyclonal
Host
Goat
Gene
EPM2A
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 0.1 - 0.3 ug/ml
  • Immunohistochemistry 2.5 - 3.8 ug/ml
  • Immunohistochemistry-Paraffin 2.5 - 3.8 ug/ml
  • Peptide ELISA Detection limit 1:16000
Application Notes
WB: Approx. 38 kDa band observed in human brain (cerebellum), mouse brain and rat brain lysates (calculated MW of 37.2 kDa band according to NP_005661.1). IHC-P: Human cerebellum shows pixulate staining in the cells of the granular layer.
Publications
Read Publication using NBP1-18846.

Reactivity Notes

Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine, Bovine.

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
Preservative
0.02% Sodium Azide
Concentration
0.5 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Laforin/EPM2A Antibody

  • EC 3.1.3.16
  • EC 3.1.3.48
  • epilepsy, progressive myoclonus type 2, Lafora disease (laforin)
  • epilepsy, progressive myoclonus type 2A, Lafora disease (laforin)
  • EPM2
  • EPM2A
  • Lafora PTPase
  • Laforin
  • LAFPTPase
  • LD
  • LDE
  • MELF

Background

This gene encodes a dual-specificity phosphatase that associates with polyribosomes. The encoded protein may be involved in the regulation of glycogen metabolism. Mutations in this gene have been associated with myoclonic epilepsy of Lafora. Alternative splicing results in multiple transcript variants. [provided by RefSeq]

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Laforin/EPM2A Antibody (NBP1-18846)(1)

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Bioinformatics

Gene Symbol EPM2A
Entrez
Uniprot