Kv5.1 Antibody (NG8)

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Product Details

Summary
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    • Catalog Number
      NBP1-42553
    • Availability
      Product Discontinued

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Kv5.1 Antibody (NG8) Summary

Immunogen
The antibody reacts with the CNF1 antigen.
Specificity
The monoclonal antibody NG8 is specific for Cytotoxic necrotizing factor type 1 (CNF1) of uropathogenic Escherichia coli. CNF1 and CNF2 belong to a family of bacterial toxins that target the small GTP-binding Rho proteins that regulate the actin cytoskeleton. Members of this toxin family typically inactivate Rho; however, CNF1 and the highly related CNF2 activate Rho by deamidation. CNF1 is more frequently associated with E.coli strains that cause extraintestitinal infections in humans, particularly those of the urinary tract (such as cystitis, pyelonephritis and prostatitis). In CNF1-producing uropathogenic E. coli strains, CNF1 is chromosomally encoded and typically resides on a pathogenicity island that also contains hemolysin and P fimbria- related genes. Both CNF1 and the highly related, plasmid-encoded CNF2 are monomeric, cytoplasmic toxins of approximately 115 kDa. CNF1 can be structurally organized into three functional domains the N-terminal, central and the C-terminal domain. The latter exhibits the catalytic activity of the toxin. Monoclonal antibody NG8 recognizes an epitope between amino acids 704 and 730 of the C-terminal enzymatic domain. NG8 specifically neutralizes CNF1 while lacking activity for CNF2.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
KCNF1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
Application Notes
The monoclonal antibody NG8 can be used for immuno assays, Western blotting and native dot blot analyses. Furthermore the monoclonal antibody NG8 is useful for inhibition of biological activity.For Western blotting dilutions to be used depend on detection system applied. It is recommended that users test the reagent and determine their own optimal dilutions. The typical starting working dilution is 1:10. For inhibition of biological activity in vitro dilutions have to be made according to the amounts of CNF1 to be inactivated.

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS, containing 0.1% bovine serum albumin.
Preservative
No Preservative
Purity
Protein A or G purified

Alternate Names for Kv5.1 Antibody (NG8)

  • IK8
  • kH1
  • KV5.1
  • MGC33316
  • potassium channel KH1
  • potassium channel Kv5.1
  • potassium voltage-gated channel subfamily F member 1
  • potassium voltage-gated channel, subfamily F, member 1
  • voltage-gated potassium channel subunit Kv5.1

Background

Potassium channels contribute to maintaining cell volume, membrane potential, neuronal excitability and the secretion of transmitters, salt and hormones. Two families of potassium channels have been identified. One family includes the inwardly rectifying potassium channels whereas, the other family includes: voltage sensing (KV); big conductance, calcium activated (BKca); and small conductance, calcium activated (SK) potassium channels. KCNF1 (Potassium voltage-gated channel, subfamily F, member 1) is a voltage-gated potassium (Kv) channel.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KCNF1