Ku80/XRCC5 Antibody

Images

 
Western Blot: Ku80/XRCC5 Antibody [NB100-92129] - Analysis of XRCC5 (A717) pAb at 1:500 dilutionLane1:HEK293T whole cell lysate Lane2:Raw264.7 whole cell lysate
Immunohistochemistry-Paraffin: Ku80/XRCC5 Antibody [NB100-92129] - Analyzes of XRCC5 (A717) pAb in paraffin-embedded human breast carcinoma tissue at 1:100.
Western Blot: Ku80/XRCC5 Antibody [NB100-92129] - Analysis of XRCC5 (A717) antibody in extracts fromJurkat cells.
Immunohistochemistry-Paraffin: Ku80/XRCC5 Antibody [NB100-92129] - Paraffin-embedded human breast carcinoma tissue.

Product Details

Summary
Product Discontinued
View other related Ku80/XRCC5 Primary Antibodies

Order Details


    • Catalog Number
      NB100-92129
    • Availability
      Product Discontinued

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Ku80/XRCC5 Antibody Summary

Immunogen
Synthetic peptide, corresponding to amino acids 700-730 of Human Ku-86.
Clonality
Polyclonal
Host
Rabbit
Gene
XRCC5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:1000
  • Immunohistochemistry 1:50-1:200
  • Immunohistochemistry-Paraffin 1:50-1:200
Application Notes
Western blot (WB) analysis of XRCC5 (A717) pAb in extracts fromJurkat cells.
Immunohistochemistry (IHC) analyzes of XRCC5 (A717) pAb in paraffin-embedded human breast carcinoma tissue.
Theoretical MW
82 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Positive Control
Ku80/XRCC5 Lysate (NBL1-17918)
Publications
Read Publication using
NB100-92129 in the following applications:

  • WB
    1 publication

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.2)
Preservative
0.05% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Ku80/XRCC5 Antibody

  • 80kDa
  • ATP-dependent DNA helicase 2 subunit 2
  • ATP-dependent DNA helicase II 80 kDa subunit
  • CTC85
  • CTCBF
  • EC 3.6.4.-
  • FLJ39089
  • G22P2
  • KARP1
  • KARP-1
  • Ku80
  • Ku86 autoantigen related protein 1,86 kDa subunit of Ku antigen
  • Ku86
  • Ku86DNA repair protein XRCC5
  • KUB2
  • NFIV
  • Thyroid-lupus autoantigen
  • TLAA
  • X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining)CTC box-binding factor 85 kDa subunit
  • X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80kD)
  • X-ray repair cross-complementing protein 5
  • X-ray repair, complementing defective, repair in Chinese hamster
  • XRCC5

Background

The x-ray repair cross-complementing (XRCC) proteins are responsible for efficiently repairing and maintaining genetic stability following DNA base damage. These genes share sequence similarity with the yeast DNA repair protein Rad5. XRCC1 is a 70 kDa protein that facilitates the DNA base excision repair pathway by interacting with DNA ligase III and DNA polymerase to repair DNA single-strand breaks. XRCC2 and XRCC3 are both involved in maintaining chromosome stability during cell division. XRCC2 is required for efficient repair of DNA double-strand breaks by homologous recombination between sister chromatids, and XRCC3 interacts directly with Rad51 to cooperate with Rad51 during recombinational repair. XRCC4 is an accessory factor of DNA ligase IV that preferentially binds DNA with nicks or broken ends. XRCC4 binds to DNA ligase IV and enhances its joining activity, and it is also involved in V(D)J recombination. Any defect in one of the known components of the DNA repair/V(D)J recombination machinery (Ku-70, Ku-80, DNA-PKCS, XRCC4 and DNA ligase IV) leads to abortion of the V(D)J rearrangement process and early block in both T and B cell maturation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Publications for Ku80/XRCC5 Antibody (NB100-92129)(1)

We have publications tested in 1 confirmed species: Human.

We have publications tested in 1 application: WB.


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(1)
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Product General Protocols

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Video Protocols

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Positive Control Lysate(s)

Secondary Antibodies

 

Isotype Controls

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Bioinformatics Tool for Ku80/XRCC5 Antibody (NB100-92129)

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Bioinformatics

Gene Symbol XRCC5
Entrez