KCNH1 Antibody [DyLight 405]

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Product Details

Summary
Product Discontinued
View other related KCNH1 Primary Antibodies

Order Details


    • Catalog Number
      NBP1-42816V
    • Availability
      Product Discontinued

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KCNH1 Antibody [DyLight 405] Summary

Immunogen
Synthetic peptide made to an internal portion of rat KCNH1 (within residues 400-450).[Swiss-Prot# Q63472]
Localization
Membrane; Multi-pass membrane protein.
Specificity
This antibody does not cross-react with Kv1.2.
Clonality
Polyclonal
Host
Rabbit
Gene
KCNH1
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot
  • Immunocytochemistry/Immunofluorescence
  • Immunohistochemistry
Application Notes
This KCNH1 antibody is useful for Immunoprecipitation, Immunocytochemistry/Immunofluorescence and Western blot, where a band can be seen at ~110 kDa.

The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Human, mouse, rat, bovine and other vertebrates.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for KCNH1 Antibody [DyLight 405]

  • EAG channel 1
  • EAG1
  • EAGeag1
  • Ether-a-go-go potassium channel 1
  • ether-a-go-go, Drosophila, homolog of
  • hEAG1
  • h-eageag
  • Kv10.1
  • MGC142269
  • potassium channel, voltage-gated, subfamily H, member 1
  • potassium voltage-gated channel subfamily H member 1
  • potassium voltage-gated channel, subfamily H (eag-related), member 1
  • Voltage-gated potassium channel subunit Kv10.1

Background

KCNH1 (potassium voltage-gated channel subfamily H member 1) is a voltage-gated potassium channel with canonical tetrameric structure and six-transmembrane domain topology. KCNH1 gene was originally named ether a go-go (eag) as its mutation in Drosophila melanogaster induced a rhythmic leg-shaking phenotype under ether anesthesia, and hence also referred as aseag1 or Kv10.1. KCNH1 mutant fruit flies shows a high frequency of spontaneous action potentials and increased transmitter release in motor neurons. In mammals, KCNH1 expression is restricted to brain, where its specific neuronal functions are largely unknown. One of the known KCNH1 physiological functions is its promoting role at the onset of myoblast fusion. KCNH1 has been suspected to play important pathophysiological role in carcinogenesis because the human, KCNH1 gene is overexpressed in a broad spectrum of cancers and its inhibition leads to reduction in cell proliferation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol KCNH1