Kallikrein 3/PSA Antibody

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Immunohistochemistry-Paraffin: Prostate Specific Antigen Antibody [NB100-62865] - Human Prostate stained with Sheep anti Human Prostate Specific Antigen

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NB100-62865
    • Availability
      Product Discontinued

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Kallikrein 3/PSA Antibody Summary

Immunogen
Purified human prostate specific antigen from human seminal fluid.
Localization
Cytoplasmic and Secreted
Specificity
NB100-62865 is specific for human prostate specific antigen, a 33-34 kD glycoprotein with chymotrypsin-like protease activity. NB100-62865 shows minimal cross reactivity in gel diffusion with serum proteins: albumin, retinol binding protein, IgG and alpha-1-microglobulin.
Isotype
IgG
Clonality
Polyclonal
Host
Sheep
Gene
KLK3
Purity
Protein G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • ELISA 1:100-1:2000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:1000

Reactivity Notes

Human. Not yet tested in other species.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.09% Sodium Azide
Concentration
5 mg/ml
Purity
Protein G purified

Alternate Names for Kallikrein 3/PSA Antibody

  • APS seminin
  • EC 3.4.21
  • EC 3.4.21.77
  • Gamma-seminoprotein
  • hK3
  • Kallikrein 3
  • kallikrein 3, (prostate specific antigen)
  • Kallikrein-3
  • kallikrein-related peptidase 3
  • KLK2A1
  • KLK3
  • P-30 antigen
  • prostate specific antigen
  • prostate-specific antigen
  • PSA semenogelase
  • PSA
  • Semenogelase
  • Seminin

Background

Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Its protein product is a protease present in seminal plasma. It is thought to function normally in the liquefaction of seminal coagulum, presumably by hydrolysis of the high molecular mass seminal vesicle protein. Serum level of this protein, called PSA in the clinical setting, is useful in the diagnosis and monitoring of prostatic carcinoma. Alternate splicing of this gene generates two transcript variants encoding different isoforms. Additional transcript variants have been described, but it is unclear if these transcripts are normally expressed or if they are specific to benign or malignant tumors.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol KLK3
Entrez
Uniprot