Flow Cytometry: Jagged 1 Antibody (HMJ1-29) [PE] [NBP2-00234] - Staining of CD8+CD11c+ C57BL/6 splenocytes with 0.5 ug of Armenian Hamster IgG Isotype Control PE (blue histogram) or 0.5 ug of Anti-Mouse CD339 (Jagged 1) ...read more
Alternate Names for Jagged 1 Antibody (HMJ1-29) [PE]
This HMJ1-29 monoclonal antibody reacts with mouse Jagged-1, one of five type I transmembrane proteins that serves as a Notch receptor ligand. Upon binding the Notch receptor (e.g. Notch 1-4), Jagged-1 undergoes proteolytic cleavage, first by ADAM-family metalloproteases and then by ?-secretase. The second cleavage event releases an intracellular fragment whose biological function remains controversial. Jagged-1 is expressed by thymic lymphoid and stromal cells, as well as macrophages and CD8+CD11c+ dendritic cells in the spleen.
This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.