JAB1 Antibody (2B12)

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Western Blot: JAB1 Antibody (2B12) [NBP2-01813] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY JAB1 (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ...read more
Immunocytochemistry/ Immunofluorescence: JAB1 Antibody (2B12) [NBP2-01813] Staining of COS7 cells transiently transfected by pCMV6-ENTRY JAB1.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human tonsil using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human kidney tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human liver tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human lung tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human bladder tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human Kidney tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human Ovary tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human pancreas tissue using anti-JAB1 mouse monoclonal antibody.
Immunohistochemistry-Paraffin: JAB1 Antibody (2B12) [NBP2-01813] - Staining of paraffin-embedded Human prostate tissue using anti-JAB1 mouse monoclonal antibody.

Product Details

Summary
Reactivity Hu, MkSpecies Glossary
Applications WB, ICC/IF, IHC, IHC-P
Clone
2B12
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

JAB1 Antibody (2B12) Summary

Immunogen
Full length human recombinant protein of human COPS5(NP_006828) produced in HEK293T cell.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
COPS5
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Immunocytochemistry/Immunofluorescence 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for JAB1 Antibody (2B12)

  • COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
  • COP9 signalosome complex subunit 5
  • COPS5
  • CSN5
  • CSN5COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5
  • EC 3.4
  • JAB1
  • JAB138 kDa Mov34 homolog
  • Jun activation domain-binding protein 1
  • MOV-34
  • SGN5
  • SGN5MGC3149
  • Signalosome subunit 5

Background

The protein encoded by this gene is one of the eight subunits of COP9 signalosome, a highly conserved protein complex that functions as an important regulator in multiple signaling pathways. The structure and function of COP9 signalosome is similar to that of the 19S regulatory particle of 26S proteasome. COP9 signalosome has been shown to interact with SCF-type E3 ubiquitin ligases and act as a positive regulator of E3 ubiquitin ligases. This protein is reported to be involved in the degradation of cyclin-dependent kinase inhibitor CDKN1B/p27Kip1. It is also known to be an coactivator that increases the specificity of JUN/AP1 transcription factors. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

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Bioinformatics

Gene Symbol COPS5
Entrez
Uniprot