Recombinant Human ITPA Protein

Images

 
Western Blot: ITPA Protein [NBP1-45292] - 15% SDS-PAGE (3ug)

Product Details

Summary
Reactivity HuSpecies Glossary
Applications PAGE
Concentration
1 mg/ml

Order Details

Recombinant Human ITPA Protein Summary

Description
A recombinant protein with a N-Terminal His-tag and corresponding to the amino acids 1-194 of Human ITPA

Source: E.coli

Amino Acid Sequence: MGSSHHHHHH SSGLVPRGSH MMAASLVGKK IVFVTGNAKK LEEVVQILGD KFPCTLVAQK IDLPEYQGEP DEISIQKCQE AVRQVQGPVL VEDTCLCFNA LGGLPGPYIK WFLEKLKPEG LHQLLAGFED KSAYALCTFA LSTGDPSQPV RLFRGRTSGR IVAPRGCQDF GWDPCFQPDG YEQTYAEMPK AEKNAVSHRF RALLELQEYF GSLAA

Source
E. coli
Protein/Peptide Type
Recombinant Protein
Gene
ITPA
Purity
>95% pure by SDS-PAGE

Applications/Dilutions

Theoretical MW
23.7 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
20mM Tris-HCl buffer (pH8.0) containing 10% glycerol
Preservative
No Preservative
Concentration
1 mg/ml
Purity
>95% pure by SDS-PAGE

Alternate Names for Recombinant Human ITPA Protein

  • C20orf37
  • dJ794I6.3
  • EC 3.6.1
  • EC 3.6.1.19
  • HLC14-06-P
  • inosine triphosphatase (nucleoside triphosphate pyrophosphatase)
  • Inosine triphosphatase
  • inosine triphosphatase-A
  • inosine triphosphate pyrophosphatase
  • inosine triphosphate pyrophosphohydrolase
  • ITPase
  • My049 protein
  • nucleoside triphosphate diphosphatase
  • Putative oncogene protein hlc14-06-p

Background

ITPA, also known as Inosine triphosphate pyrophosphatase, is an enzyme that catalyzes the pyrophosphohydrolysis of both ITP (inosine triphosphate) and dITP (deoxyinosine triphosphate) to IMP (inosine monophosphate) and diphosphate. IMP can be used as a substrate for purine nucleotide pathways. IMP can be phosphorylated to ITP, and ITPA can regulate the concentration of ITP in the cell by converting ITP back to IMP. Defects in ITPA result in ITPA deficiency which is thought to be inherited and is characterized by an over-accumulation of ITP in erythocytes, leukocytes and fibroblasts. Recombinant human ITPA protein, fused to His-tag at N-terminus, was expressed in E.coli and purified by using conventional chromatography techniques.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Peptides and proteins are guaranteed for 3 months from date of receipt.

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Bioinformatics

Gene Symbol ITPA