ITM2C Antibody - Azide and BSA Free

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Western Blot: ITM2C Antibody [NBP3-04539] - Analysis of extracts of various cell lines, using ITM2C antibody at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) at 1:10000 dilution. Lysates/proteins: ...read more

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB
Clonality
Polyclonal
Host
Rabbit
Conjugate
Unconjugated
Format
Azide and BSA Free

Order Details

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Catalog# & Formulation Size Price

ITM2C Antibody - Azide and BSA Free Summary

Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ITM2C (NP_001012532.1). MVKISFQPAVAGIKGDKADKASASAPAPASATEILLTPARLARDNFFRCGVLYEDSLSSQVRTQMELEEDVKIYLDENYERINVPVPQFGGGDPADIIHDFQRGLTAYHDISLDKCYVIELNTTIVLPPRNFWELLMNVKRGTYLPQTYIIQEEMVVTEHVSDKEALGSFIYHLCNGKDTYRLRRRATRRRINKRGAKNCNAIRHFENTFVVETLICGVV
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
ITM2C
Purity
Affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:2000

Packaging, Storage & Formulations

Storage
Store at -20C. Avoid freeze-thaw cycles.
Buffer
PBS with 50% glycerol, pH7.3.
Preservative
0.01% Thimerosal
Purity
Affinity purified

Alternate Names for ITM2C Antibody - Azide and BSA Free

  • BRI3
  • BRI3E25C
  • BRICD2C
  • BRICHOS domain containing 2C
  • Cerebral protein 14
  • E25
  • hRPC.1050_D_4
  • integral membrane protein 2C
  • integral membrane protein 3
  • ITM2C
  • ITM3
  • Transmembrane protein BRI3

Background

ITM2C also known as Integral membrane protein 2C, has 3 isoforms, an isoform 1that is 267 amino acid and 30 kDa, an isoform 2 that is 220 amino acid and 25 kDa, and an isoform 3 that is 230 amino acid and 26 kDa; most commonly found in the brain tissue; acts as negative regulator of beta amyloid peptide production, may inhibit the processing of APP by blocking its access to alpha- and beta-secretase, appears to be a poor gamma-secretase cleavage inhibitor, and may play a role in TNF-induced cell death and neuronal differentiation. Studies are being performed on the relationship of this protein to anemia of prematurity, cerebritis, anemia, dementia, influenza, gastric cancer, and neuronitis. The protein has been shown to interact with BACE1, APP, STMN2, STT3A, RNF7, and FURIN proteins in negative regulation of neuron projection development, induction of programmed cell death, and neuron differentiation pathways.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

Additional ITM2C Products

Array NBP3-04539

Research Areas for ITM2C Antibody (NBP3-04539)

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Bioinformatics

Gene Symbol ITM2C