ITM2B Antibody (1C11)

Images

 
Western Blot: ITM2B Antibody (1C11) [NBP2-00620] - HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY ITM2B (Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates ...read more
Immunohistochemistry-Paraffin: ITM2B Antibody (1C11) [NBP2-00620] Staining of paraffin-embedded Human Kidney tissue using anti-ITM2B mouse monoclonal antibody.
Flow Cytometry: ITM2B Antibody (1C11) [NBP2-00620] - Analysis of Jurkat cells, using anti-ITM2B antibody, (Red), compared to a nonspecific negative control antibody (Blue).
Flow Cytometry: ITM2B Antibody (1C11) [NBP2-00620] - Analysis of Hela cells, using anti-ITM2B antibody, (Red), compared to a nonspecific negative control antibody (Blue).

Product Details

Summary
Reactivity HuSpecies Glossary
Applications WB, Flow, IHC, IHC-P
Clone
1C11
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Order Details

ITM2B Antibody (1C11) Summary

Immunogen
Full length human recombinant protein of human ITM2B (NP_068839) produced in HEK293T cell.
Isotype
IgG2a
Clonality
Monoclonal
Host
Mouse
Gene
ITM2B
Purity
Immunogen affinity purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Western Blot 1:2000
  • Flow Cytometry 1:100
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Paraffin 1:150

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS (pH 7.3), 1.0% BSA and 50% Glycerol
Preservative
0.02% Sodium Azide
Purity
Immunogen affinity purified

Alternate Names for ITM2B Antibody (1C11)

  • ABRI
  • ABri/ADan amyloid peptide
  • BRI
  • BRI2
  • BRICD2B
  • BRICHOS domain containing 2B
  • BRIFBD
  • E25B
  • E3-16
  • FBD
  • integral membrane protein 2B
  • ITM2B
  • Protein E25B
  • Transmembrane protein BRI

Background

Amyloid precursor proteins are processed by beta-secretase and gamma-secretase to produce beta-amyloid peptides which form the characteristic plaques of Alzheimer disease. This gene encodes a transmembrane protein which is processed at the C-terminus by furin or furin-like proteases to produce a small secreted peptide which inhibits the deposition of beta-amyloid. Mutations which result in extension of the C-terminal end of the encoded protein, thereby increasing the size of the secreted peptide, are associated with two neurogenerative diseases, familial British dementia and familial Danish dementia. [provided by RefSeq].

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ITM2B
Entrez