IRGC Antibody

Images

 
Western Blot: IRGC Antibody [NBP1-77363] - A20 cell lysate with IRGC antibody at (A) 1 and (B) 2 ug/ml.
Immunocytochemistry/ Immunofluorescence: IRGC Antibody [NBP1-77363] - Immunofluorescence of IRGCa in A20 cells with IRGCa antibody at 20 ug/mL.
Immunocytochemistry/ Immunofluorescence: IRGC Antibody [NBP1-77363] - A20 cells with IRGC antibody at 5 ug/ml.

Product Details

Summary
Product Discontinued
View other related IRGC Primary Antibodies

Order Details


    • Catalog Number
      NBP1-77363
    • Availability
      Product Discontinued

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IRGC Antibody Summary

Immunogen
Antibody was raised against a 13 amino acid peptide near the amino terminus of human IRGC
Clonality
Polyclonal
Host
Rabbit
Gene
IRGC
Purity
Immunogen affinity purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Western Blot 1:100-1:2000
  • ELISA 1:100-1:2000
  • Immunocytochemistry/Immunofluorescence 1:10-1:2000

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.02% Sodium Azide
Concentration
1 mg/ml
Purity
Immunogen affinity purified

Alternate Names for IRGC Antibody

  • CINEMA
  • EC 3.6.5
  • EC 3.6.5.-
  • Iigp5
  • Immunity-related GTPase cinema 1
  • immunity-related GTPase family, cinema 1
  • immunity-related GTPase family, cinema
  • interferon inducible GTPase 5
  • interferon-inducible GTPase 5
  • IRGC1
  • R30953_1

Background

Immunity-related GTPases (IRG) (also known as p47 GTPases) are a family of GTPase proteins found in vertebrates, which play critical roles in mediating innate resistance to intracellular pathogens. IRG genes have been found in a number of mammals and lower species including mice, rats, zebrafish and humans. Most of the mouse genes contain interferon-stimulated response elements which mediate transcriptional activation by IFNs. In humans, only two IRG genes have been found: human IRGC encodes a full-length IRG protein that, like the mouse homologue, is constitutively expressed in testis, while human IRGM encodes a considerably truncated protein that is constitutively expressed in cultured cells including some macrophage cell lines. As the two human genes IRGC and IRGM are not subject to IFN control, it has been suggested that the host resistance mechanism supported by IRG proteins in the mouse is lacking in humans. Two isoforms of IRGC are known to exist; this antibody will only recognize the IRGCa isoform.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol
ICC/IF Video Protocol

FAQs for IRGC Antibody (NBP1-77363) (0)

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Secondary Antibodies

 

Isotype Controls

Additional IRGC Products

IRGC NBP1-77363

Bioinformatics Tool for IRGC Antibody (NBP1-77363)

Discover related pathways, diseases and genes to IRGC Antibody (NBP1-77363). Need help? Read the Bioinformatics Tool Guide for instructions on using this tool.
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Diseases for IRGC Antibody (NBP1-77363)

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Pathways for IRGC Antibody (NBP1-77363)

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Contact Information

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Calculators

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Bioinformatics

Gene Symbol IRGC
Uniprot