Involucrin Antibody (SY5) [Alexa Fluor® 700]

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Product Details

Summary
Reactivity Hu, Po, Ca, Pm, Mu(-)Species Glossary
Applications WB
Clone
SY5
Clonality
Monoclonal
Host
Mouse

Involucrin Antibody (SY5) [Alexa Fluor® 700] Summary

Immunogen
Purified involucrin from human keratinocytes
Localization
Cytoplasmic
Marker
Squamous Cell Terminal Differentiation Marker
Specificity
It recognizes a protein of 66kDa-170kDa, identified as involucrin. In Western blotting of cultured human keratinocytes, this MAb reacts with a 120kDa protein. It stains the involucrin in a variety of sizes: 170kDa in MCF-7 cells, a doublet of ~115kDa and 150kDa in gorilla and owl monkey, 66kDa in dog, and a doublet of 105kDa in pig. Its epitope maps between codon 421-568 of human involucrin. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea, which lacks a distinct cornified layer. In normal epidermis, it is first expressed in the upper spinous layers, and in keratinocyte cultures, all cells that have left the basal layer express it. Involucrin expression is altered in pathological conditions: in psoriasis and other benign epidermal hyperplasias, involucrin expression begins closer to the basal layer than normal; expression is abnormal in squamous cell carcinomas and premalignant lesions, and is reduced in severe dysplasias of the larynx and cervix.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
IVL
Purity
Protein A purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Packaging, Storage & Formulations

Storage
Store at 4C in the dark.
Conjugate
Alexa Fluor 700
Format
Alexa Fluor 700 (A=675-700, E=723)
Buffer
50mM Sodium Borate
Preservative
0.05% Sodium Azide
Purity
Protein A purified

Applications/Dilutions

Dilutions
  • Western Blot

Reactivity Notes

Gorilla, Owl Monkey

Alternate Names for Involucrin Antibody (SY5) [Alexa Fluor® 700]

  • involucrin

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Product General Protocols

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Video Protocols

WB Video Protocol

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Secondary Antibodies

 

Isotype Controls

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Involucrin NBP2-34719AF700

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Contact Information

Product PDFs

Bioinformatics

Gene Symbol IVL

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