Integrin beta 7 Antibody (MAB0859)

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Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP2-22002
    • Availability
      Product Discontinued

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Integrin beta 7 Antibody (MAB0859) Summary

Immunogen
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells from a rat immunized with mouse Integrin beta 7 lysate. Myeloid leukemia cell line (TK-1).
Isotype
IgG2
Clonality
Monoclonal
Host
Rat
Gene
ITGB7
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Blocking/Neutralizing 50-200 molar excess
  • Flow Cytometry 1:50-1:250
Application Notes
Extremely low level of LPS (< 0.002EU/ug IgG)

Reactivity Notes

Mouse

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
A 0.2 um filtered solution in PBS - Azide free
Preservative
No Preservative
Concentration
LYOPH
Purity
Protein A or G purified
Reconstitution Instructions
Reconstitute with sterilized PBS.

Alternate Names for Integrin beta 7 Antibody (MAB0859)

  • Gut homing receptor beta subunit
  • integrin beta 7 subunit
  • Integrin beta 7
  • integrin beta-7
  • integrin, beta 7
  • ITGB7

Background

ICOS, a protein of 47-57kD, is also known as inducible costimulatory molecule and H4. This protein is homologous to the CD28/CTLA-4 proteins. ICOS is expressed on activated T cells and a subset of thymocytes and can costimulate T cells and induce proliferation. In addition ICOS has been shown to be involved in humoral immune responses (B cell germinal center formation). The ICOS ligand, B7h/B7RP-1 and B7-H2 is constitutively expressed in B cell areas of secondary lymphoid organs and can be induced in other tissues by LPS. ICOS stimulation has been shown to potentiate TCRmediated IL-4 and IL-10 production and has been proposed to play a role in Th2 cell development. ICOS stimulation has been shown to be involved in airway tolerance and the downregulation of pulmonary inflammation.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGB7
Entrez