Integrin beta 7 Antibody (FIB504) [Biotin]

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Flow Cytometry: Integrin beta 7 Antibody (FIB504) [Biotin] [NBP1-43538] - Staining of normal human peripheral blood cells with Anti-Human CD3 APC and 0.125 micrograms of Rat IgG2a k Isotype Control Biotin (left) or 0.06 ...read more

Product Details

Summary
Product Discontinued
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Order Details


    • Catalog Number
      NBP1-43538
    • Availability
      Product Discontinued

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Integrin beta 7 Antibody (FIB504) [Biotin] Summary

Immunogen
TK1 cells
Specificity
Integrin beta 7 (FIB504)
Isotype
IgG2a Kappa
Clonality
Monoclonal
Host
Rat
Gene
ITGB7
Purity
Protein A or G purified
Innovator's Reward
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
Each lot of this antibody is quality control tested by immunofluorescent staining with flow cytometric analysis. For immunofluorescent staining, the suggested use of this reagent is: 1.0 microgram per one million cells in 100 microliter volume. It is recommended that the reagent be titrated for optimal performance for each application.
Readout System

Reactivity Notes

Expected Cross-Reactivity based on immunogen sequence: Chimpanzee, Baboon, Cynomolgus, Rhesus.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Aqueous buffer, may contain carrier protein/stabilizer (proprietary)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Integrin beta 7 Antibody (FIB504) [Biotin]

  • Gut homing receptor beta subunit
  • integrin beta 7 subunit
  • Integrin beta 7
  • integrin beta-7
  • integrin, beta 7
  • ITGB7

Background

The FIB504 monoclonal antibody reacts with human and mouse integrin beta7. Integrin beta7 is a 130 kD glycoprotein which associates with integrin alpha4 (CD49d) to form the alpha4beta7 integrin LPAM-1, expressed on intraepithelial lymphocytes. It also associates with alphaE (CD103) to form the alphaEbeta7 integrin HML-1, expressed on T cells adjacent to mucosal epithelium and intraepithelial lymphocytes. Main ligands for integrin alpha4beta7 include VCAM-1 (CD106), MAdCAM-1 and fibronectin, while the main ligand of integrin alphaEbeta7 is E-cadherin (CD324). Integrin beta7 plays an important role in the adhesion of leukocytes to endothelial cells promoting the transmigration of leukocytes to extravascular spaces during the inflammatory response. The FIB504 antibody has been reported to have blocking activity.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Secondary Antibodies

 

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Bioinformatics

Gene Symbol ITGB7
Entrez