Integrin beta 3/CD61 Antibody (2C9.G2) [FITC]

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Flow Cytometry: Integrin beta 3/CD61 Antibody (2C9.G2) [FITC] [NB100-77444] - C57BL/6 mouse bone marrow cells stained with HMa3-1 FITC

Product Details

Summary
Product Discontinued
View other related Integrin beta 3/CD61 Primary Antibodies

Order Details


    • Catalog Number
      NB100-77444
    • Availability
      Product Discontinued

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Integrin beta 3/CD61 Antibody (2C9.G2) [FITC] Summary

Immunogen
Vitronectin receptor protein from the mouse T-cell hybridoma 2B4
Specificity
CD61 (2C9.G2 )
Isotype
IgG
Clonality
Monoclonal
Host
Armenian Hamster
Gene
ITGB3
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
Application Notes
Additional reported applications (for the relevant formats) include: blocking of ligand binding, activation of Alpha-v beta-3 integrin signaling, and immunohistochemical staining of acetone-fixed frozen sections.

Reactivity Notes

Mouse, Rat.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
PBS (pH 7.2)
Preservative
0.09% Sodium Azide
Concentration
0.5 mg/ml
Purity
Protein A or G purified

Alternate Names for Integrin beta 3/CD61 Antibody (2C9.G2) [FITC]

  • CD61 antigen
  • CD61
  • GP3A
  • GP3Aplatelet glycoprotein IIIa
  • GPIIIA
  • GPIIIaintegrin beta-3
  • INGRB3
  • Integrin beta 3
  • integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
  • ITG B3
  • ITGB3
  • Platelet membrane glycoprotein IIIa

Background

CD61 is a 110 kD integrin beta chain also known as beta3 integrin or gpIIIa. It associates with the integrin alphav chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin alphaIIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of alphav/ beta3 integrin or vitronectin receptor to CD31 (PECAM-1). The 2C9.G2 antibody reacts with mouse and rat CD61, and is able to block ligand binding.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGB3
Entrez