Integrin alpha L/CD11a Antibody (87-6F9)

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Product Details

Summary
Reactivity MuSpecies Glossary
Applications Flow, IHC, IHC-Fr, CyTOF-ready
Clone
87-6F9
Clonality
Monoclonal
Host
Mouse
Conjugate
Unconjugated

Integrin alpha L/CD11a Antibody (87-6F9) Summary

Immunogen
The antibody reacts with the CD11a antigen.
Specificity
CD11a is expressed on lymphocytes, granulocytes, monocytes and macrophages with increase in levels on memory T cells. CD11a or LFA-1 has a key role in mediating leukocyte adhesion to endothelium during inflammatory responses through binding to ICAM-1 (CD54). Other ligands are ICAM-2 and ICAM-3. It is also involved in many T cell functions and immune phenomena. Mol. weight in SDS gels is about 180 kD. Part of heterodimer with CD18 (integrin beta-2). A defect in beta-2 expression results in leucocytes adhesion deficiency (LAD) in which patients suffer from recurring bacterial infections. Source: A BALB/c mouse was immunized and SP2/0 cells were used for fusion with splenocytes.
Isotype
IgG1
Clonality
Monoclonal
Host
Mouse
Gene
ITGAL
Purity
Protein A or G purified
Innovator's Reward
Test in a species/application not listed above to receive a full credit towards a future purchase.

Applications/Dilutions

Dilutions
  • Flow Cytometry 1:10-1:1000
  • Immunohistochemistry 1:10-1:500
  • Immunohistochemistry-Frozen 1:10-1:500
  • CyTOF-ready
Application Notes
MoAbs are used for prevention of graft-versus-host disease. Also used to determine LFA-1 immunodeficiency.

Reactivity Notes

Please note that this antibody is reactive to Mouse and derived from the same host, Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
No buffer
Preservative
No Preservative
Purity
Protein A or G purified

Alternate Names for Integrin alpha L/CD11a Antibody (87-6F9)

  • CD11 antigen-like family member A
  • CD11a antigen
  • CD11a
  • CD11Aantigen CD11A (p180), lymphocyte function-associated antigen 1, alphapolypeptide
  • Integrin alpha L
  • integrin alpha-L
  • integrin gene promoter
  • integrin, alpha L (antigen CD11A (p180), lymphocyte function-associated antigen1; alpha polypeptide)
  • ITGAL
  • Leukocyte adhesion glycoprotein LFA-1 alpha chain
  • Leukocyte function-associated molecule 1 alpha chain
  • LFA-1 alpha
  • LFA-1
  • LFA1A
  • LFA-1A
  • Ly-15
  • Ly-21
  • lymphocyte function-associated antigen 1

Background

CD11a is a member of the integrin family of cell adhesion molecules. It is a glycoprotein expressed in combination with the CD18 beta chain. The complex is a member of the beta 2 integrin family. These molecules function in cell adhesion and specifically bind to CD54, ICAM2, ICAM3. CD11a is expressed on thymocytes, T and B lymphocytes, granulocytes, monocytes, and macrophages. This antibody blocks CD11a functions. CD11a is expressed on human leucocytes, with greater expression on memory T cells.

Limitations

This product is for research use only and is not approved for use in humans or in clinical diagnosis. Primary Antibodies are guaranteed for 1 year from date of receipt.

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Bioinformatics

Gene Symbol ITGAL
Entrez